Abstract: Objective To study the β-catenin gene expression and inhibitory effects ondiffused malignant plural mesothelioma tissues. MethodsB NCI-H28 cell apoptosis was detected with the techniques of Annexin V and TUNEL.The inhibitory effect of β-catenin was observed with incubation in vitro.Results The cells transferring wild β-catenin（β-CAT-V5-FP）and mutant β-catenin （β-CAT-S37C-V5-FP）were increased signifcantly compared with blank carrier group. The β-catenin gene transferring carboxyl absent also resulted in apoptosis, but the apoptotic rate was lower than those of cells transferring wild β-catenin（β-CAT-V5-FP）and mutant β-catenin （β-CAT-S37C-V5-FP）. Conclusion β-catenin gene can induce apoptosis on non-epithelioid tumor-diffused malignant plural mesothelioma.

Key words: β-catenin, apoptosis