Abstract:

Abstract:Objective  To observe the effects of Soft Capsule of Compound Oil of Jujube,Arboruitae,and Gardenia (COJAG) on serum estrogen hormone,blood rheology,blood fats,as well as body weight and viscera indexes in castrated female rats. Methods 45 bilateral oophorectomy female rats were divided into COJAG high,middle and low doses groups,estrogen group,and model group; other 10 rats were used as  sham operation group. The blood fats,blood rheology,body weight,viscera indexes,serum estrodiol,follicle-stimulating hormone and luteinizing hormone were determined. Results Compared with model group, the serum E2 was significantly increased (P<0.01),FSH (P<0.05) and LH (P<0.01) were reduced; TG,TC,LDL,and C/HDL-C were significantly reduced (P<0.05),HDL-C was increased (P<0.05); the body weight of the female castrated rats was significantly reduced and their thymus,pituitary,uterus,adrenal and other organs’ viscera indexes were increased (P<0.05 or P<0.01). The ηb and ηp in high,middle and low shear rates of whole blood viscosity,plasma viscosity were significantly lowered (P<0.05),ESR was speeded up (P<0.05),and the Hct and Fib were lowered (P<0.05) in the female castrated rats in COJAG groups. Conclusion COJAG can decrease blood fat,improve blood rheology,reduce weight,and increase viscera index; these roles are probably related to the increase of estrogen content in blood and(or) its rich polyunsaturated fatty acids.

Key words: Soft Capsule of Compound Oil of Jujube,Arboruitae,and Gardenia, estrodiol, follicle-stimulating hormone, luteinizing hormone, blood lipid, body mass index, viscera index;blood rheology