Abstract:

Abstract:Objective  To study the effect of Lipid-lowering Mixture(LM) on blood lipid profile and blood hemorheology of hyperlipidemia rats，and to elucidate the mechanism of LM on regulating blood lipid and hemorhelogy. Methods  60 male Wistar rats were randomly divided into  normal control group, model control group,simvastatin group and LM high,middle, low doses groups,and there were 10 rats in each group.The rats in normal control group were fed with normal  diet,and  the rats in the other groups were fed with a high fat diet to establish hyperlipidemia rat models, and during the modeling the drugs were  used for prevention.2 mL physiological saline were given to the rats in control group and model group,and the rats in simvastatin group  were given 7.2×10-4g/mLsimvastatin suspension solution 2 mL, and the rats in LM low, middle,high doses groups were given 0.25,0.50,1.00 g/mL decoction 2 mL,the once  daily dose  lasted for 10 weeks.After 10 weeks,the rats in 6 groups were  eyeballed blood, the blood lipid profile and blood hemorheology of each  animal in various groups were measured by full automatic biochemical analyzer and full automatic blood analyzer,respectively.Results Compared with model group, after  treatment, the levels of the cholesterol (TC ), triglyceride ( TG ),low density lipoprotein ( LDL-C ) and  apolipoprotein B ( ApoB ) in LM  groups were reduced; the high density lipoprotein ( HDL-C ), apolipoprotein A ( ApoA ) levels and apoA / apoB ratio were increased, the differences were statistically significant ( P<0.05 or P<0.01).Compared with model group, the plasma viscosity（ηp）, whole blood viscosity ( low, medium, high cut ) （ηb）, index of erythrocyte aggregation ( IEA ), hematocrit (HCT ),and erythrocyte electrophoresis time ( EET ) in LM groups were decreased, the index of erythrocyte deformability ( IED ) was increased, the differences were statistically significant ( P<0.05 or P<0.01).Conclusion LM can modulate blood lipid metabolism and blood viscosity, poly, and prothrombotic state of the experimental hyperlipidemia rats, which has better regulation and inhibition  on blood lipid and blood flow abnormalities.

Key words: lipid-lowering mixture, hyperlipidemia, lipid profile, apolipoprotein, blood rheology