J4 ›› 2011, Vol. 37 ›› Issue (5): 792-796.

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Process conditions and parameters of purification of total flavonoid of China ixeris by macroporous resin

 WU Jin-Yi1,2, LI Xin-Jie2,CHEN Xue-Song2, DONG Xue-Lian2, QIU Zhi-Dong2   


  1. (1.Department of |Cardiology, China-Japan Union Hospital,Jilin University,Changchun |130033,China;2.School of Pharmacy,Changchun University of Chinese Medicine, Changchun 130117,China)
  • Received:2011-06-29 Online:2011-09-28 Published:2011-09-28

Abstract:

Abstract:Objective
To discuss the process conditions and parameters of macroporous resin in enrichment and purification of total flavone in order to improve the product quality of SanKu dropping pills and reduce the single dose of product.Methods The total  flavonoid of China ixeris were obtained as the quantity indexes. The process conditions of different  types of macroporous resin  D101,AB-8,DM130,D312 and NKA in purification of total flavonoid were detected by UV. Results The best purification process was  DM130 macroporous resin,centrifugal of the extract at  8 000 r•min-1,for 40 min,  70% ethanol elution.So the total flavonoid could reach 65%.Conclusion High speed centrifugal combined with macroporous resin  is good for enriching total flavonoid of Sanku dropping pills.

Key words: Sanku dropping pills;macroporous resin;purification;total flavonoids of Ixeris sonchifolia

CLC Number: 

  • R284