Abstract:

Abstract:Objective To explore the influence of low-dose dexamethasone (Dex) on the electroencephalogram (EEG) in temporal lobe epileptic male rats,and provide basis for glucocorticoid-related drugs in treatment of temproal lobe epilepsy.Methods Wistar rats were randomly divided into normal group,sham group,control group kindled with temporal lobe epilepsy after pretreated with normal saline (NS-control group) and observation group kindled with temporal lobe epilepsy pretreated with low-dose Dex (Dex group).The temporal lobe epileptic model was established via kainic acid (KA) microinjected (1 μg) into right nucleus amygdalae of  male Wistar rats.EEG on parietal lobe cortex was recorded in normal group and sham group,and EEG was monitored successively for 6 h after KA kindling in NS-control group and Dex group. Results Compared with NS-control group,the kindling latency of temporal lobe epilepsy was delayed in Dex group (P<0.05),the total lasting time of seizure discharge within 6 h was shorten (P<0.05),and the amplitude of EEG wave was significantly decreased (P<0.05).Conclusion Low-dose Dex may inhibit the epileptic discharge in temporal lobe epileptic male rats,and it indicates that low-dose Dex may be effective for curing temporal lobe epilepsy.

Key words: dexamethasone;epilepsy;kainic acid;kindling;electroencephalogram