Abstract:

Objective To detect the levels of anti-gliadin IgA and anti-gliadin IgG antibodies in the plasma of the patients with schizophrenia,and to investigate the   association between schizophrenia and anti-gliadin IgA,IgG bodies in a Chinese Han  population,and to clarify the effect of gliadin on the occurrence of schiz
ophrenia.Methods The plasma samples were collected from 428 patients with schizophrenia and 555 cases of normal control subjects in a Chinese Ha
n population.The gliadin antibodies in plasma,including IgA and IgG,were tested using a native anti-gliadin ELISA test kit.The positive rates of plasma anti-gliadin IgA,and anti-gliadin IgG were tested by Chi-square test between the patients with schizophrenia and control subjects.The differences of the levels of
 anti-gliadin IgA and anti-gliadin IgG were tested by Mann - Whitney U test between the patients with schizophrenia and control subjects.
Results Compared with normal control group,the anti-gliadin IgA level and the positive rate of plasma anti-gliadin IgA in patient group were increased significantly(P<0.01),but there were no significant differences of the positive rate and the level of anti-gliadin IgG in plasma between patient and control groups (P>0.05).The anti-gliadin IgA levels in the patients with delusion of observation,delusion of being revealed,delusion of persecution,delusion of jealousy,delusion of grandeur,incoherence of thinking,illogic thought,bizarre behavior,aggressive behavior,hallucination-delusion syndrome,poverty of thought,emotional blunting / apathy and aboulia were higher than that of the normal controls ( P<0.05);the anti-gliadin IgG levels in the patients with delusion of being revealed and delusion of grandeur were higher than that of the normal controls ( P<0.05).Conclusion Gliadin is associated with the onset of schizophrenia  in  Chinese Han  population,and the plasma antibodies of gliadin maybe play an important rale in the onset of schizophrenia.

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Key words: schizophrenia, phenotype, anti-gliadin IgA, anti-gliadin IgG, enzyme-labeled immunosorbent assay