miR-34a在牙龈鳞状细胞癌组织中的表达及其临床意义

doi:10.13481/j.1671-587x.20160611

Abstract

Abstract:

Objective: To detect the expression levels of microRNA-34a(miR-34a) in gingival squamous cell carcinoma (GSCC) tissue and adjacent tissue,and to clarify its correlation with the pathological characteristics of GSCC patients,including tumor size, malignancy degree,age,gender,tumor site and lymph node metastasis.Methods: The tissue samples including 30 GSCC tissues and matched carcinoma adjacent tissues were selected. The expression levels of miR-34a in GSCC tissue and carcinoma adjacent tissue were detected by quantitative reverse transcription-PCR(qRT-PCR) method. The relationship between its expresion level and the clinicopathological characteristics of GSCC patients were analyzed.Results: Compared with carcinoma adjacent tissue,the expression level of miR-34a in GSCC tissue was significantly decreased (t=3.03,P=0.004).The expression level of miR-34a in GSCC tissue had no relationship with the age,gender, and lymph node metastasis of the patients(P>0.05),but had relationship with the tumor size and tumor malignancy degree (P<0.05).Conclusion: The expression level of miR-34a is down-regulated significantly in GSCC tissue.The detection of the expression level of miR-34a contributes to judge the histological subtype.

Key words: microRNA 34a, carcinoma,squamous cells, gingiva, clinicopathological characteristic

CLC Number:

R780.2

CUI Leihua, JI Xin, LI Minghe, HAN Minglin, ZHANG Ning, SUNLanfang, HAN Chengmin. Expression of miRNA-34a in gingival squamous cell carcinoma tissue and its clinical significance[J].Journal of Jilin University Medicine Edition, 2016, 42(06): 1099-1103.

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Expression of miRNA-34a in gingival squamous cell carcinoma tissue and its clinical significance

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