人参黄连组合物对糖尿病肾病小鼠的治疗作用

doi:10.13481/j.1671-587x.20160612

Abstract

Abstract:

Objective: To explore the effect of Ginseng and Coptis composition on the biochemical indexes and morphology of kidney tissue in the diabetes nephrophthy (DN) mice,and to provide basis for its application in DN treatment.Methods: Ten C57 mice were selected as normal control group.A total of 240 C57 mice were induced to establish DN models by feeding with high-sugar and high-fat diet combined with small dose of streptozotocin(STZ).The DN mice were randomly divided into model control group,low(80 mg·kg^-1+20 mg·kg^-1),medium(160 mg·kg^-1+40 mg·kg^-1), and high(320 mg·kg^-1+80 mg·kg^-1) doages of Ginseng and Coptis composition groups, total alkaloid from Coptis group(320 mg·kg^-1), total Ginsenoside group(80 mg·kg^-1),and captopril group(8 mg·kg^-1); there were 10 mice in each group. After treated for 8 weeks,the physiological status of C57 mice in various groups were observed.The levels of fasting blood glucose(FBG),microalbuminuria(MAU),serum creatinine (Scr),blood urea nitrogen (BUN),total cholesterol (TC),and triglyceride(TG) of mice in various groups were measured.The pathomorphology of kidney tissue of mice was observed by HE staining.Results: Compared with model control group,the physiological status of C57 mice in different dosages of Ginseng and Coptis composition groups,such as the urine volume and the body weight increase were significantly improved,and the levels of FBG were decreased (P<0.05); the levels of MAU,BUN,TC, and TG were also decreased (P<0.05).The glomerular and renal interstitial lesions of the kidney tissue in different dosages of Giseng and Coptis composition groups were significantly improved.Conclusion: Ginseng and Coptis composition has therapeutical effect on early DN.

Key words: Ginseng and Coptis composition, diabetic nephropathy, pharmacodynamics

CLC Number:

R587

ZHANG Meishuang, ZHANG Yu, REN Boying, TANG Shan, SUN Jiaming, ZHANG Hui. Therapeutical effect of Ginseng and Coptis composition on diabetic nephropathyin mice[J].Journal of Jilin University Medicine Edition, 2016, 42(06): 1104-1107.

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Therapeutical effect of Ginseng and Coptis composition on diabetic nephropathyin mice

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