Abstract: Objective: To analyze the clinical data of a patient with epidural hematoma ossification after craniocerebral injury,and to improve the understanding and treatment level of the disease by combing the literature review. Methods: A 36-year-old man with headache and dizziness for 3 months was performed general physical examination and related imaging examination to identify the location and size of the lesion and its relationships with skull and endocranium.The patient with multiple myeloma was treated with chemotherapy for 4 months.The changes of imaging features of the intracranial lesions were judged.The diagnosis was confirmed by biopsy pathology result after operation and the patient was given the corresponding treatment. Results: The diagnosis was regarded as epidural hematoma ossification after craniocerebral injury according to the patient's imaging examination and the pathological results after operation.The diagnosis results of skull osteoma and multiple myeloma metastasis were excluded.The lesion was stable during the follow-up of two years. Conclusion: For the patient with epidural hematoma ossification after craniocerebral injury,the skull osteoma should be considered,and other bone diseases should be excluded.The imaging evidence is needed for the diagnosis.The results of biopsy pathology should be taken if necessary.

Key words: craniocerebral injury, multiple myeloma, skull osteoma, epidural hematoma ossification