PLA2G4C基因多态性与北方汉族儿童孤独症谱系障碍的关联性分析

doi:10.13481/j.1671-587x.20170116

Abstract

Abstract:

Objective: To investigate the association of PLA2G4C (phospholipase A2,group IVC) gene polymorphisms with autism spectrum disorder (ASD) in the North Han Chinese children,and to explore whether PLA2G4C is a susceptibility gene for ASD in the North Han Chinese children.Methods: A total of 85 ASD children and 183 healthy controls were included in the study.Five single nucleotide polymorphisms (SNPs)sites (rs9226,rs1045376,rs251684,rs2307279,and rs156631) in PLA2G4C were selected and their genotypes were measured using Sequenom Mass ARRAY System.SNPStats program was adopted to analyze the Hardy-Weinberg (H-W) equilibrium test,the distribution of genotypic and allelic frequencies,the association of ASD with 5 SNPs under five genetic models,and the association of ASD with haplotypes.Results: The distribution of genotypic frequencies of 5 SNPs of PLA2G4C gene in case and control groups wasn't deviated with H-W equilibrium (P>0.05).There was no significant difference in the distribution of genotypic and allelic frequencies of 5 SNPs between case and control groups (P>0.05).No significant association was found between ASD and the 5 SNPs under five genetic models (P>0.05).The haplotypes composed by the three SNPs (rs251684,rs2307279,and rs156631) were not associated with ASD (P>0.05).Conclusion: PLA2G4C may not be a susceptibility gene for ASD in the North Han Chinese children.

Key words: single nucleotide polymorphism, autism spectrum disorder, case-control study, PLA2G4C gene

CLC Number:

R749.94

QIU Shuang, LIU Shicheng, PENG Bo, LEI Jie, LI Ri, BAI Ye, YU Yaqin, ZHU Xiaojuan, LIU Yawen, JIANG Huiyi. Analysis on association of PLA2G4C gene polymorphisms with autism spectrum disorder in North Han Chinese children[J].Journal of Jilin University Medicine Edition, 2017, 43(01): 80-84.

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Analysis on association of PLA2G4C gene polymorphisms with autism spectrum disorder in North Han Chinese children

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