Abstract: Objective: To analyze the imaging features of magnetic susceptibility-weighted imaging (SWI) in the patients with cerebral amyloid angiopathy-related hemorrhage (CAAH), and to clarify the diagnostic value of SWI for CAAH. Methods: A total of 68 patients presumptively diagnosed as CAAH were collected,and their imaging data of routine MRI and SWI were collected and analyzed. The detection rates of hemorrhage focus of the CAAH patients were compared between two kinds of imaging examination. The consistency of detection of CAAH by routine MRI and SWI was analyzed. The imaging features of SWI and the risk of focus hemorrhage in the patients with CAAH were analyzed by multivariate Logistic regression analysis. Results: Sixty-one patients were confirmed as CAAH by pathologic diagnosis, and 53 patients were confirmed as CAAH by routine MRI; the detection rate was 86.89%; 59 cases of hemorrhage focus were confirmed by SWI and the detection rate was 96.72%. The number of lesions detected by SWI was more than that of routine MRI (P<0.05). The consistency of detection of CAAH by routine MRI and SWI was poor, and the value of Kappa was 0.3666. The patchy high signal and multiple clear edge low signal area were the relative imaging features of CAAH with SWI in the patients with CAAH analyzed by multivariate Logistic regression analysis (OR=3.895, P=0.025; OR=3.124, P=0.029). Conclusion: SWI can efficiently detect the hemorrhage focus in the patients with CAAH and the diagnostic value is better than routine MRI.

Key words: cerebral amyloid angiopathy, cerebral hemorrhage, magnetic susceptibility-weighted imaging, magnetic resonance imaging