Journal of Jilin University(Medicine Edition) ›› 2021, Vol. 47 ›› Issue (5): 1237-1243.doi: 10.13481/j.1671-587X.20210522
• Research in clinical medicine • Previous Articles Next Articles
Zhouguang WU,Bin WANG(),Zhen CHENG,Wenjie ZHANG,Taoyan ZUO,Siqi CHEN,Jingru FU
Received:
2021-02-05
Online:
2021-09-28
Published:
2021-10-26
Contact:
Bin WANG
E-mail:zhwuzhouguang@163.com
CLC Number:
Zhouguang WU,Bin WANG,Zhen CHENG,Wenjie ZHANG,Taoyan ZUO,Siqi CHEN,Jingru FU. Analysis on correlation of GPC3 and α-SMA expressions with liver function-related indexes in liver tissue of children with biliary atresia[J].Journal of Jilin University(Medicine Edition), 2021, 47(5): 1237-1243.
Tab. 1
General clinical data of children in two groups"
Group | n | Surgery age (t/d) | Female[n(η/%)] | ALB(g·dL-1) | TB[cB/(μmol·L-1)] | DB[cB/(μmol·L-1)] |
---|---|---|---|---|---|---|
Control | 20 | 908.23±242.25 | 14(70.00) | 4.26±0.79 | 75.07±21.89 | 59.51±18.13 |
BA | 26 | 62.21±11.20 | 16(61.54) | 4.05±0.82 | 209.65±47.44 | 154.24±37.70 |
t/χ2 | -17.843 | 0.357 | -0.875 | 11.739 | 10.321 | |
P | <0.01 | 0.550 | 0.386 | <0.01 | <0.01 | |
Group | n | ALT[λB/(IU·L-1)] | AST[λB/(IU·L-1)] | ALP[λB/(IU·L-1)] | γ-GGT[λB/(IU·L-1)] | Metavir score |
Control | 20 | 52.26±22.89 | 45.48±12.87 | 296.12±60.43 | 42.28±13.14 | 1.08(0.57,1.98) |
BA | 26 | 101.85±26.48 | 112.89±48.26 | 679.45±115.71 | 110.15±46.40 | 3.01(2.28, 3.34) |
t/χ2 | 6.671 | 6.069 | 13.449 | 6.334 | 8.021 | |
P | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 |
Tab. 3
Analysis on correlations of GPC3 and α-SMA protein expression levels in liver tissue with liver function indexes of patients in two groups"
Item | Index | Age (t/d) | ALB (g·dL-1) | TB[cB/ (μmol·L-1)] | DB[cB/ (μmol·L-1)] | ALT [λB/(IU·L-1)] | AST [λB/(IU·L-1)] | ALP [λB/(IU·L-1)] | γ-GGT [λB/(IU·L-1) | Metavir score |
---|---|---|---|---|---|---|---|---|---|---|
GPC3 | r | -0.384 | -0.514 | 0.126 | -0.103 | 0.014 | -0.327 | 0.582 | 0.165 | 0.468 |
P | 0.026 | 0.005 | 0.234 | 0.315 | 0.815 | 0.035 | 0.008 | 0.126 | 0.016 | |
α-SMA | r | 0.022 | -0.162 | -0.093 | -0.089 | -0.102 | -0.045 | 0.465 | 0.176 | 0.422 |
P | 0.723 | 0.120 | 0.421 | 0.435 | 0.287 | 0.521 | 0.016 | 0.113 | 0.010 |
Tab. 4
Expression levels of GPC3 and α-SMA proteins in liver tissue of and Metavir scores of patients in different prognostic groups"
Group | n | CPC3(η/%) | α-SMA(η/%) | Metavir score |
---|---|---|---|---|
Good prognosis | 18 | 25.06(8.77,40.21) | 20.11(6.23,32.67) | 1.11(0.52,1.35) |
Poor prognosis | 8 | 62.23(52.23,71.27) | 47.22(24.12,50.23) | 3.37(2.78,3.92) |
Z | 5.822 | 4.209 | 6.579 | |
P | <0.01 | <0.01 | <0.01 |
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