Journal of Jilin University(Medicine Edition) ›› 2021, Vol. 47 ›› Issue (2): 257-264.doi: 10.13481/j.1671-587X.20210202
• Research in basic medicine • Previous Articles Next Articles
Rongjun JIA1,Liman MA2,Lihua LI1()
Received:
2020-09-17
Online:
2021-03-28
Published:
2021-03-25
Contact:
Lihua LI
E-mail:2744900797@qq.com
CLC Number:
Rongjun JIA,Liman MA,Lihua LI. Protective effect of calcitriol on hepatic fibrosis induced by bile duct ligation in mice and its mechanism[J].Journal of Jilin University(Medicine Edition), 2021, 47(2): 257-264.
Tab.1
Activities of serum ALT and AST and levels of TBA, TBIL and Hyp of mice in various groups"
Group | ALT[λB/(U·L-1)] | AST[λB/ (U·L-1)] | TBA[cB/ (μmol·L-1)] | TBIL[cB/ (μmol·L-1)] | Hyp [ρB/ (mg·L-1)] |
---|---|---|---|---|---|
Sham operation | 50.22±4.72 | 26.53±2.34 | 4.21±1.02 | 36.02±4.28 | 1.73±0.16 |
Model | 187.43±27.30* | 146.94±16.58* | 12.26±1.43* | 266.22±39.05* | 3.22±0.18* |
Treatment | 122.56±7.38*△ | 66.68±5.96*△ | 5.38±1.20*△ | 135.78±12.44*△ | 2.05±0.26*△ |
Tab.2
Expression levels of ERK,p-ERK,α-SMA, TGF-β1, Col Ⅰ and Desmin proteins in liver tissue of mice in various groups"
Group | ERK | p-ERK | α-SMA | TGF-β1 | Col Ⅰ | Desmin |
---|---|---|---|---|---|---|
Sham operation | 0.58±0.02 | 0.63±0.01 | 0.14±0.02 | 0.22±0.04 | 0.30±0.02 | 0.49±0.11 |
Model | 1.15±0.04* | 1.27±0.03* | 0.40±0.03* | 0.49±0.07* | 1.66±0.03* | 0.83±0.02* |
Treatment | 0.61±0.02△ | 0.66±0.05△ | 0.27±0.09△ | 0.26±0.01△ | 0.55±0.01△ | 0.61±0.06△ |
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