吉林大学学报(工学版) ›› 2013, Vol. 43 ›› Issue (05): 1427-1432.doi: 10.7964/jdxbgxb201305043

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Pulse dye densitometry method for non-invasive measurement of hepatic functional reserves

LIU Guang-da1, HUANG Jing-tao1, LU Meng-meng1, ZHANG Xiao-feng1, XIN Gui-jie2, JIN Sheng-lai1   

  1. 1. College of Instrumentation and Electrical Engineering, Jilin University, Changchun 130061, China;
    2. First Hospital of Jilin University, Changchun 130021, China
  • Received:2012-07-06 Online:2013-09-01 Published:2013-09-01

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Abstract:

The exist several problems in current measurement of hepatic functional reserves, such as multiple blood samplings for spectrophotometry, lower precision and longer time taken by manual operation, and possible infection risk. In order to solve these problems, a noninvasive and continuous method based on pulse sepctrophotometry for detection of hepatic functional reserves is presented by setting up and analyzing Indocyanine Green (ICG) dye dilution and clearance curves. While ICG is injected intravenously, two light sources at 940 nm and 805 nm wavelengths are used to implement data acquisition by Photoplethysmography (PPG). The ICG disappearance rate in blood plasma (K value) and 15 min retention ratio (R15 value) as hepatic functional reserves parameters can be determined by calculating time-varying ICG concentration values. Compared with blood sampling method, the mean relative error of this new method is below 5%. The results confirm its usefulness in evaluating hepatic functional reserves for clinical liver removal surgery.

Key words: information processing technology, hepatic functional reserves, pulse dye densitometry, indocyanine green (ICG), absorption coefficient

CLC Number: 

  • TN911.7

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