1 | ANGIN P, YOLDEMIR T, ATASAYAN K. Quality of life among infertile PCOS patients[J]. Arch Gynecol Obstet, 2019, 300(2): 461-467. |
2 | BEHBOODI MOGHADAM Z, FEREIDOONI B, SAFFARI M, et al. Measures of health-related quality of life in PCOS women: a systematic review[J]. Int J Womens Health, 2018, 10: 397-408. |
3 | NICHOLSON J K, LINDON J C. Systems biology: Metabonomics[J].Nature, 2008,455(7216):1054-1056. |
4 | XI Y L, WU M Z, LI H X, et al. Baicalin attenuates high fat diet-induced obesity and liver dysfunction: dose-response and potential role of CaMKKβ/AMPK/ACC pathway[J]. Cell Physiol Biochem, 2015, 35(6): 2349-2359. |
5 | HUANG W H, LEE A R, YANG C H. Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI[J]. Biosci Biotechnol Biochem, 2006, 70(10): 2371-2380. |
6 | FANG P H, YU M, ZHANG L, et al. Baicalin against obesity and insulin resistance through activation of AKT/AS160/GLUT4 pathway[J]. Mol Cell Endocrinol, 2017, 448: 77-86. |
7 | FANG P H, YU M, SHI M Y, et al. Baicalin and its aglycone: a novel approach for treatment of metabolic disorders[J]. Pharmacol Rep, 2020, 72(1): 13-23. |
8 | LI F F, ZHANG Z, WANG P, et al. ALC1 knockdown enhances cisplatin cytotoxicity of esophageal squamous cell carcinoma cells by inhibition of glycolysis through PI3K/Akt pathway[J]. Life Sci, 2019, 232: 116679. |
9 | LIU J S, HUO C Y, CAO H H, et al. Aloperine induces apoptosis and G2/M cell cycle arrest in hepatocellular carcinoma cells through the PI3K/Akt signaling pathway[J]. Phytomedicine, 2019, 61: 152843. |
10 | YU Z P, YU H Q, LI J,et al. Troxerutin attenuates oxygen-glucose deprivation and reoxygenation-induced oxidative stress and inflammation by enhancing the PI3K/AKT/HIF-1α signaling pathway in H9C2 cardiomyocytes [J]. Mol Med Rep, 2020, 22(2):1351-1361. |
11 | 杨 意. miRNA-320通过PI3K/AKT信号通路调控多囊卵巢综合征大鼠胰岛素抵抗的实验研究[D]. 武汉: 武汉大学, 2018. |
12 | ZHANG N, LIU X Y, ZHUANG L L, et al. Berberine decreases insulin resistance in a PCOS rats by improving GLUT4: Dual regulation of the PI3K/AKT and MAPK pathways[J]. Regul Toxicol Pharmacol, 2020, 110: 104544. |
13 | QIU Z X, DONG J J, XUE C, et al. Liuwei Dihuang Pills alleviate the polycystic ovary syndrome with improved insulin sensitivity through PI3K/Akt signaling pathway[J]. J Ethnopharmacol, 2020, 250: 111965. |
14 | TESSARO I, MODINA S C, FRANCIOSI F, et al. Effect of oral administration of low-dose follicle stimulating hormone on hyperandrogenized mice as a model of polycystic ovary syndrome[J]. J Ovarian Res, 2015, 8: 64. |
15 | 朱晓艳, 季兰萍, 刘长跃. 醋酸环丙孕酮联合二甲双胍对多囊卵巢综合征患者内分泌及代谢影响的Meta分析[J]. 生殖与避孕, 2016, 36(3): 202-207. |
16 | 周红潮, 杜 锐, 王 慧, 等. 黄芩苷药代动力学研究进展[J]. 中国中药杂志, 2018, 43(4): 684-688. |
17 | MIAO M S, PENG M F, ZHU Z W, et al. Effects of dodder total flavone on polycystic ovary syndrome rat models induced by DHEA combined HCG[J]. Saudi J Biol Sci, 2019, 26(4): 821-827. |
18 | BHATNAGER R, JALTHURIA J, SEHRAWAT R, et al. Evaluating the association of TNF α promoter haplotype with its serum levels and the risk of PCOS: a case control study[J]. Cytokine, 2019, 114: 86-91. |
19 | 俞瑾, 俞超芹. 俞氏清肝方治疗“肝经湿热型”多囊卵巢综合征的临床疗效观察及其有效成分黄芩苷的作用机制研究[C]//中国中西医结合学会妇产科专业委员会.2016全国中西医结合妇产科研究进展学术研讨会暨2016年第一届江浙沪中西医结合妇产科高峰论坛论文集. 上海, 中国中西医结合学会妇产科专业委员会,2016: 61-64. |
20 | CAMERON J L, JAIN R, RAIS M, et al. Perpetuating effects of androgen deficiency on insulin resistance[J]. Int J Obes (Lond), 2016, 40(12): 1856-1863. |
21 | 陈慧玲, 郑连文, 路英丽, 等. PCOS中低度慢性炎症相关因子的研究进展[J]. 中国妇幼保健, 2016, 31(9): 2007-2011. |
22 | SARRAY S, ALMAWI W Y. Levels of CD40L and other inflammatory biomarkers in obese and non-obese women with polycystic ovary syndrome[J]. Am J Reprod Immunol, 2016, 76(4): 285-291. |
23 | ZHAO Y, ZHANG C M, HUANG Y, et al. Up-regulated expression of WNT5a increases inflammation and oxidative stress via PI3K/AKT/NF-κB signaling in the granulosa cells of PCOS patients[J]. J Clin Endocrinol Metab, 2015, 100(1): 201-211. |
24 | ZHAO H X, ZHOU D C, CHEN Y, et al. Beneficial effects of Heqi San on rat model of polycystic ovary syndrome through the PI3K/AKT pathway[J]. DARU, 2017, 25(1): 21. |
25 | 李萌芳, 陈隆望, 胡系意, 等. 黄芩苷对脂多糖诱导的H9C2心肌细胞炎症的保护作用及机制研究 [J]. 中华急诊医学杂志, 2019, 28(8):983-988. |
26 | 李子涵, 张 宁, 张建霞. 慢性炎症与多囊卵巢综合征的关系及相关研究进展[J]. 国际生殖健康/计划生育杂志, 2018, 37(3): 243-246. |
27 | WU C Y, JIANG F, WEI K, et al. Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5α-reductase type 1 in PCOS rats[J]. Sci Rep, 2018, 8(1): 7982. |
28 | 邓 姗, 郎景和. 孕激素与子宫内膜异位症发生机制的研究进展[J]. 中华妇产科杂志,2004,39(12):848-850. |
29 | 管海云, 张 炜. 多囊卵巢综合征对子宫内膜容受性的影响[J]. 生殖医学杂志, 2016, 25(12): 1122-1125. |
30 | 邵 洋, 杨婷婷, 张 洁, 等. 二甲双胍通过PI3K-AKT-MDm2通路对PCOS患者子宫内膜的影响[J]. 实用药物与临床, 2019, 22(12): 1275-1278. |