吉林大学学报(医学版)

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血管紧张素原基因M235T多态性与肥厚型心肌病关系的Meta分析

陈 玲,金 楠,李 革   

  1. 重庆医科大学公共卫生与管理学院流行病学教研室,重庆 400016
  • 收稿日期:2013-07-09 出版日期:2014-01-28 发布日期:2014-01-25
  • 通讯作者: 李 革(Tel:023-68485368,E-mail:venono05@sina.com) E-mail:venono05@sina.com
  • 作者简介:陈 玲(1987-),女,重庆市人,在读医学硕士,主要从事流行病与卫生统计学研究。
  • 基金资助:

     “十二五”国家科技支撑项目资助课题(2011BAI11B01)

Meta-analysis on association between angiotensinogen gene M235T
 polymorphism and hypertrophic cardiomyopathy

CHEN Ling,JIN Nan,LI Ge   

  1. Department of Epidemiology,School of Public Health and Management,Chongqing Medical University,Chongqing 400016,China
  • Received:2013-07-09 Online:2014-01-28 Published:2014-01-25

摘要:

目的:系统评价血管紧张素原(AGT)基因M235T多态性与肥厚型心肌病(HCM)
的相关性,为HCM的防治提供依据。方法:检索PubMed、Embase、OVID、Web of Science、Cochranelibrary、CNKI、万方及VIP数据库,搜集有关AGT M235T多态性与HCM关系研究的文献,对符合纳入标准的文献采用Stata 11.0软件进行Meta分析。结果:共纳入8篇文献,累计病例887例,对照组1 407例。Meta分析,M235T基因多态性与HCM的相关性差异无统计学意义[T vs M:OR=1.17,95%CI=0.95~1.45;(TT/MT) vs MM:OR=1.12,95%CI=0.87~1.45;TT vs
 (MM/MT):OR=1.21,95%CI=1.00~1.45;MT vs MM:OR=1.07,95%CI=0.82~1.41;TT vs MM:OR=1.25,95%CI=0.79~1.99]。亚组分析,M235T基因多态性与亚洲人群和散发性肥厚型心肌病(SHCM)有关,差异均有统计学意义(P<0.05),在欧洲和家族性肥厚型心肌病(FHCM)人群中差异无统计学意义(P>0.05)。结论:在全人群中AGT M235T多态性与HCM的发病无关联,但是在亚洲和SHCM的人群中M235T多态性与HCM的发病有关。

关键词: 血管紧张素原, 基因多态性, 肥厚型心肌病, Meta分析

Abstract:

Objective To investigate the relationship between angiotensinogen (AGT) gene M235T polymorphism and hypertrophic cardiomyopathy(HCM) and to provide e
vidence for prevention and treatment of HCM. Methods PubMed,Embase,OVID,Web of Science,Cochranelibrary,CNKI,WangFang Data and VIP were searched to identify the studies about the relationship between AGT M235T polymorphism and HCM.The studies that met the inclusion criteria were used for Meta-analysis with Stata 11.0 software.Results  Eight studies were included,which involved 887 cases and 1 407 controls. The Meta-analysis results indicated that there was no

significant association between AGT M235T polymorphism and HCM(T vs M:OR=1.17,95%CI=0.95-1.45;(TT/MT) vs MM:OR=1.12,95%CI=0.87-1.45;TT vs (MM/MT):OR=1.21,95%CI=1.00-1.45;MT vs MM:OR=1.07,95%CI=0.82-1.41;TT vs MM :OR=1.25,95%CI=0.79-1.99. In subgroup analysis,the significant difference of association between AGT M235T polymorphism and HCM existed in Asian and sporadic hypertrophic cardiomyopathy (SHCM),but no significant difference was found in European and familial hypertrophic cardiomyopathy (FHCM).Conclusion There is no association between HCM and AGT M235T polymorphism in populations,but such a relationship exists in Asians and SHCM.

Key words: angiotensinogen, gene polymorphism, hypertrophic cardiomyopathy, Meta-analysis

中图分类号: 

  • R542.2