关键词: 门静脉, 肝硬化, 实验性, 西咪替丁, 血流动力学

Abstract: Objective To investigate the effects of Cimetidine on portal hemodynamics in dogs with cirrhosis and portal hypertension. Methods Cirrhosis and portal hypertension were successfully induced in eleven dogs. These dogs were then divided into Cimetidine group (n=7) and saline control group (n=4),selected other 4 dogs as a normal group. Phisiological polygraph, electromagnetic flowmeters and other devices were used to detect the changes of portal and systemic hemodynamics in the normal group,saline control group, and Cimetidine group after portal hypertensive dogs in Cimetidine group were injected intravenously with Cimetidine (0.012 g•kg^-1 weight) and portal hypertensive dogs in salme control group with normal saline. Results In Cimetidine group，5，15，30，60，90, and 120 minutes after cimetidine injection, free portal pressure decreased 5.2% (P<0.05),14.1% (P<0.01), 13.7%(P<0.01),12.9%(P<0.01),9.3%（P<0.01）,6.5%(P<0.05), respectively. Wedged hepatic venous pressure, hepatic venous pressure gradient, portal venous resistance decreased synchronously. There was no significant change in hepatic arterial flow. Portal venous flow and total hepatic flow slightly increased. There were no significant changes in free hepatic venous pressure, inferior vena cava pressure, mean aorta arterial pressure and heart rate. The maximum decreased value of free portal pressure was significantly positively correlated to the histamine concentrations of femoral vein blood (r=0.787 4, P<0.05). No significant changes of any indexes mentioned above were found in saline control group after injection of normal saline and in normal group. Conclusion Cimetidine can reduce portal pressure, because it can reduce portal venous resistance by antagonizing the action of histamine. Cimetidine can slightly increase portal venous flow and has no bad effects on systemic hemodynamics.

Key words: portal, liver cirrhosis, experimental, cimetidine, hemodynamics