关键词: 镇痛, 疼痛, 痛阈

Abstract: Objective To observe the antalgic effects and addiction of Armadillidium of water abstracts (AVW) isolated from Armadillidium Vulgare in mice. Methods The mice writhing nociceptive test, hot-plate nociceptive test, the rat radiate hot irradiating nociceptive test, the mice tail-erecting test and the mice jumping test were used to study the pharmacodynamics effects of the analgesia and addiction of AVW in mice. Results AVW had obvious inhibitory effects on the mice writhing nociception and the effects increased in a dose-dependent manner. The three groups with different dosages of AVW could obviously increase the pain threshold in mice by hot-plate nociceptive test. AVW of 150 and 300 mg·kg^-1 decreased the sensitivities of the rat radiate hot irradiating nociception. There were obvious differences between administration group, pre-administration group and control group in the hot-plate and the rat radiate hot irradi ating nociceptive tests（P<0.05 or P<0.01）. Addiction was not found while AVW were administrate repeatedly and regularly. Conclusion AVW have obvious inhibitory effects in some pain models and have not addition.

Key words: analgesia, pain, pain thresh old