关键词: 心血管, 肿瘤坏死因子, 受体, 肿瘤坏死因子, 胎盘

Abstract: Objective To investigate the functions of tumor necrosis factor-alpha (TNFα) and tumor necrosis factor receptor (p55 TNFR) on the process of normal pregnancy and the pathogenesis in pregnancy-induced hypertension syndrome (PIH). Methods Placental tissues were collected with cesarean-section in 12 normal pregnant women and 43 PIH women. TNFα and p55 TNFR expressions in placental tissues were detected by immunohistochemical technique. Results The results demonstrated that TNFα and p55 TNFR were expressed in placental tissues in both normal pregnant and PIH groups. The staining degrees in patients with moderate and severe PIH were higher than those in the groups of normal pregnancy and mild PIH (P>0.05). In severe and moderate PIH groups, the staining degrees of maternal side of placental tissue were higher than that of fetal side (P<0.01).Conclusion TNF-α and p55 TNFR expressions in small scale in n ormal pregnant women may participate to regulate the normal pregnancy, whereas the over expression of TNF-α and p55 TNFR in placenta may play an important role in the pathogenesis of PIH.

Key words: cardiorvascular, tumor necrosis factor, receptors, tumor necrosis factor, placenta 