关键词: 异丙酚, 胃肿瘤, 外科学, 细胞因子类

Abstract: Objective To study the effect of ketamine and propofol on levels of perioperative plasma cytokines in gastric cancer patients underwent radical gastrectomy.Methods Forty ASAⅠ-Ⅱ patients with gastric cancer were randomly divided into ketamin group(Kt group,n=20)and propofol(Pf group,n=20),peripheral vennes blood samples were taken before anesthesia,1 h after skin incision,at the end of surgery and 24 h after operation.The plasma TNF-α,IL-6,IL-8 and IL-10 levels were determined respectively with ELISA methods.Results The levels of plasma TNF-α,IL-6 and IL-8 at 1 h after incision,at the end of surgery,and 24 h after operation in Kt group were increased,but there were no significant differences compared with before anesthesia(P>0.05).In Pf group,the levels of plasma TNF-α,IL-6 and IL-8 at 1 h after skin incision and the end of surgery were higher than those before anesthesia and those in Kt group （P<0.05 or P<0.01）.In Kt group,the level of plasma IL-10 was increased,but there was no significant difference compared with before anesthesia（P>0.05）.The plasma IL-10 level in Pf group was increased obviously compared with before anesthesia（P<0.05）.Conclusion Ketamine and propofol anesthesia can lead to take proinflammatory and antinflammatory cytokines in gastric cancer patients underwent radical gastrectomy,and keep balance between of them.Ketamine had more obviously antiflammatory effect than propofol.

Key words: propofol, gastric neopalsms, surgery, cytokines