关键词: 复方参草颗粒；脂肪肝, 酒精性；胆固醇；天冬氨酸氨基转移酶类；丙氨酸转氨酶；大鼠, Wistar

Abstract:

Objective
To investigate the effect of Compound Shencao Granules(CSCG) on biochemistry indicators in serum and the pathologic changes of liver tissue in rats suffered from alcoholic fatty liver.Methods Sixty rats were divided into six groups (n=10):control group,model group,Zhikeqing Capsule (ZKQC) group,CSCG(high,middle and low doses) groups.The rats in control group were fed with full forage,the rats in  the other groups  were fed with high fat forage plus 380 mL?L-1 of alcohol for 15 d.After successing for the model preparation,the rats in each group were fed on corresponding drugs for 40 d.12 h after the last administration，the blood samples were collected from abdomen-artery and the contents of total cholesterol (TC),triglyeride (TG),low density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C),alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected,TC/HDL-C,LDL-C/HDL-C and atherogenie index (AI) were calculated.The rats were put to death by cutting through the head,and their anatomized livers were dyed with HE and examined by light microscope.Results Compared with model group,the levels of TC,TG,LDL-C,TC/HDL-C,LDL-C/HDL-C and AI in high dose CSCG group were significantly decreased（P<0.05 or P<0.01),HDL-C was increased (P<0.01) and AI was decreased (P<0.01);under hight microscope, the ingredients of lipid droplet in CSCG groups（high and middle doses）were significantly reduced and the hepatic cells were relieved.Conclusion CSCG has antagonistic effect on alcoholic fatty liver in rats.

Key words: Compound Shencao Granules;fatty liver,alcoholic;cholestrol;aspartate aminotransferases;alaninase;rats,Wistar