吉林大学学报(医学版) ›› 2013, Vol. 39 ›› Issue (3): 578-583.doi: 10.7694/jldxyxb20130332

• 基础研究 • 上一篇    下一篇

CYP11B2基因多态性与缺血性脑卒中关联性的Meta分析

林慧中1，林 涛2，陈 慧3   

  1. 1. 福建医科大学附属协和医院心内科,福建  福州 350004；2. 福建医科大学公共卫生
    学院流行病与卫生统计学系,福建 福州 350004；3. 福建省立医院心内科，福建  福州 350003
  • 收稿日期:2012-10-21 出版日期:2013-05-28 发布日期:2013-07-01
  • 通讯作者: 陈 慧(Tel：0591-87557768，E-mail：chen.hui@medmail.com.cn) E-mail:chen.hui@medmail.com.cn
  • 作者简介:林慧中（1981-），女，福建省福州市人，医师，医学硕士，主要从事心脑 血管病的基础、临床和循证医学的研究。
  • 基金资助:

     福建省自然科学基金重点项目资助课题(C0420003)

Association between CYP11B2 gene polymorphisms and
ischemic stroke：a Meta-analysis


LIN Hui-zhong1，LIN Tao2，CHEN Hui3   

  1. 1. Department of Cardiovascular Medicine，Union Hospital,Fujian Medical Univers
    ity,Fuzhou 350004,China;2．Department of Epidemiology and Health Statistics，School of Public Health，
    Fujian University，Fuzhou 350004，China；3. Department of Cardiovascular Medicine,Fujian Provincial Hospital,Fuzhou 3
    50003,China
  • Received:2012-10-21 Online:2013-05-28 Published:2013-07-01

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摘要： 目的：对醛固酮合成酶基因CYP11B2的（-344C/T)基因位点多态性与缺血性脑
卒中（IS）的关联性进行Meta分析，为IS的治疗提供依据。方法：联合检索1990－2012
年中国期刊全文数据库、中国生物医学文献数据库、维普中文期刊数据库、万方数据库、Pu
bMed和Cochrane Collaboration Database电子数据库。采用RevMan 5.0软件对纳入文
献进行Meta分析，并进一步进行异质性检验、敏感性分析和偏倚评估。结果：共纳入6篇相关
文献。IS组与对照组TT/(TT +CC)合并OR (95% CI) 值为1.51 ( 1.06,2.16,P<0.
05)。大动脉粥样硬化性脑卒中(LAA)组与对照组TT/(TT+CC)合并OR (95% CI) 值为1.85(1.11,3.08,P<
0.05);多发腔隙性脑卒中或小动脉闭塞性脑卒中(MLI)组与对照组TT/(TT +CC)合并OR ( 95% CI)
值为2.46(1.21，4.99,P<0.05)。结论: CYP11B2基因TT基因型与IS有关联性,TT基因型与LAA和MLI亦有关联性，提示CYP11B2基因可能为IS的遗传候
选基因。

关键词: 醛固酮合成酶, 缺血性脑卒中, 基因多态性,  , Meta分析

Abstract: Objective To investigate the association between aldosterone synthase CYP11B2 (-344C/T)
gene polymorphism and ischemic stroke (IS) by Meta-analysis and to provide evide
nce for the treatment of IS.Methods Case-control studies on the association between CYP11B2 gene polymorphism and IS
 from  1990 to 2012 were collected from China national knowledge internet,Chinese biological medicine disk,Vip fulltext database,Wanfang fulltext database,PubMed and Cochrane Collaboration Database.Meta-analysis was carried out after strict screening.Heterogeneity test，sensitivity analysis and publication bias assessment were also performed.Results A total of 6 studies were included.In IS group,the pooled OR ( 95% CI ) of TT ／(TT + CC) genotype was 1.51( 1.06,2.16,P<0.05). In large artery atherosclerotic stroke LAA group,the pooled OR (95% CI ) of
TT/(TT + CC) genotype was 1.85(1.11,3.08,P<0.05).In multiple lacunar stroke (MLI) group,the pooled OR
(95% CI) of TT/ (TT + CC) genotype was 2.46(1.21,4.99,P<0.05).Conclusion The TT genotype of CYP11B2 gene is associated with IS,a
nd TT genotype is also associated with LAA and MLI,which indicats that CYP11B2 gene
is possiblely the candidate gene of IS.

Key words: CYP11B2 , ischemic stroke, gene polymorphism, Meta-analysis

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  • R734.3
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