吉林大学学报(医学版)

• 基础研究 • 上一篇    下一篇

2009-2012年内蒙古自治区急性呼吸道感染患儿呼吸道合胞病毒感染的检测及分布特征

卢爱桃1,郭卫东1,李昕1,王文瑞1,跃华1,于晶峰2   

  1. 1.内蒙古自治区疾病预防控制中心传染病预防控制所,内蒙古 呼和浩特010031;2.内蒙古医科大学基础医学院寄生虫学教研室,内蒙古 呼和浩特010110
  • 收稿日期:2013-08-26 出版日期:2014-03-28 发布日期:2014-05-28
  • 通讯作者: 于晶峰(Tel:0471-6266059,E-mail:1184474898@qq.com) E-mail:1184474898@qq.com
  • 作者简介:卢爱桃(1980-),女,内蒙古自治区呼和浩特市人,副主任检验师,农学博士,主要从事传染病预防控制的研究。
  • 基金资助:

    内蒙古自治区科技厅自然科学基金资助课题(2013MS1147)

Detection of respiratory syncytial virus infection of children infected with  acute respiratory tract infection in Inner Mongolia from 2009 to 2012 and its distribution characteristics

LU Ai-tao1,GUO Wei-dong1,LI Xin1,WANG Wen-rui1,YUE Hua1,YU Jing-feng2   

  1. 1.Department of Infectious Diseases Prevention and Control,Inner Mongolia Center for Diseases Prevention and Control,Hohhot 010031,China;2.Department of Parasites,  School of Basic Medical Sciences,Inner Mongolia Medical University,Hohhot 010110,China
  • Received:2013-08-26 Online:2014-03-28 Published:2014-05-28

摘要:

目的:了解内蒙古自治区14岁以下儿童急性呼吸道感染患者中呼吸道合胞病毒(RSV)的感染状况,阐明内蒙古自治区儿童RSV感染的流行趋势。方法:收集2009年1月—2012年10月内蒙古中、东和西部地区14岁以下儿童急性呼吸道感染及肺炎病例标本共3 207份,采用实时荧光RT-PCR法扩增RSV的部分基因片段。对不同时间、不同年龄和不同地区的样本的RSV阳性率进行分析。结果:检测的3 207份样本中,阳性样本224份,阳性率为6.98%。RSV全年均可检出,检出率高峰期主要集中在10月到次年的3月份。不同年龄段对RSV的易感性不同,3岁以下儿童RSV感染高于与3岁以上儿童(χ2=31.89,P<0.01)。1~6月龄婴儿的感染率(19.61%)最高,然后随着年龄的增加感染率逐渐下降。不同性别感染率之比为男性∶女性=1.37∶1。RSV感染病例在内蒙古东、中和西部地区均有分布,无明显的地域差异(χ2=0.207,P>0.05)。结论:RSV在内蒙古自治区全区流行,发病高峰期为冬春季节,3岁以下儿童为高发人群。

关键词:  , 呼吸道感染, 呼吸道合胞病毒, 实时荧光RT-PCR, 儿童

Abstract:

Objective
To study the sitiation of respiratory syncytial virus(RSV) infection of the  children under 14 years old with acute respiratory infection in Inner Mongolia,and to clarify the epidemiology trend of RSV infection of children in Inner Mongolia.Methods From January 2009 to October 2012,3 207 acute respiratory infections and pneumonia samples from the  children under 14 years old  were collected in west,middle,and east areas of Inner Mongolia.Part of RSV genes were amplified by real-time fluorescence RT-PCR method.The RSV positive rates of samples were analyed between different areas,ages,and months.Results 224 positive samples were detected from 3 207 samples,the positive rate was 6.98%.RSV can be detected all of the year,the detection rate reached the  peak period  from October to March of the following year.The patients with different ages had different susceptibilities for RSV,and the RSV infection rate of the patients under 3 years old was higher than that of the  patients over 3 years old(χ2=31.89,P<0.01).1-6 months infants had the highest infection rate(19.61%),and the infection rates were gradually declined as the age increasing.The patients with different genders  had different infection rates,male∶female =1.37∶1.The RSV infected patients   distributed in east,middle,and west areas of Inner Mongolia,and there were no significant  differences of RSV infection between the patients in different areas(χ2=0.207,P>0.05).Conclusion RSV  distributes in all Inner Mongolia regions,and the peak period of incidence  is the winter and spring;the children under 3 years old have high susceptibility.

Key words: respiratory infection, respiratory syncytial virus, real-time fluorescence RT-PCR, child

中图分类号: 

  • R725.6