中药联合利培酮治疗精神分裂症有效性及安全性的Meta分析

doi:10.13481/j.1671-587x.20160424

摘要/Abstract

摘要：

目的：探讨中药联合利培酮治疗精神分裂症的有效性及安全性，为其临床应用提供依据。方法：计算机检索Cochrane、PubMed、EMBase、中国期刊全文数据库、万方数据库、维普数据库以及手工检索已发表的中药联合利培酮治疗精神分裂症的临床随机对照试验及半随机对照试验，纳入符合标准的文献，纳入文献的方法学质量评价参考Cochrane Handbook，采用RevMan5.2软件进行Meta分析。结果：共纳入15篇文献，其中有11篇文献为C级，共计1314例患者纳入分析。Meta分析，中药联合利培酮治疗组较单独应用利培酮组患者临床有效率高，组间比较差异有统计学意义（OR=2.11，95%CI：1.59~2.81，P < 0.01）；中药联合利培酮组患者药物不良反应（失眠、锥体外系反应及静坐不能）发生率低于单独应用利用培酮组，组间比较差异有统计学意义（OR=0.25，95%CI：0.17~0.36，P < 0.01）。结论：中药联合利培酮较单独应用利培酮更能有效治疗精神分裂症并减少药物不良反应的发生。

关键词: 精神分裂症, 中药, 利培酮, Meta分析, 系统评价

Abstract:

Objective: To approach the effectiveness and safety of traditional Chinese medicine combined with risperidone in the treatment of schizophrenia, and to provide basis for their application in clinic. Methods: The Cochrane, Pubmed, EMBase, CNKI, Wanfang and VIP databases were used to retrieve the randomized controlled trials (RCTs) and CCTs about traditional Chinese medicine combined with risperidone in the treatment of schizophrenia by computer;and manual retrieval was performed at the same time.The literatures met the standard were collected.The qualities of all the included studies were assessed by Cochrane Handbook and Meta-analysis was performed by use of the RevMan 5.2 software. Results: Fifteen trials and 1 314 patients were included in this review. The qualities of 11 studies were grade C.The Meta-analysis results showed that the clinical effective rate in traditional Chinese medicine combined with risperidone treatment group was higher than that in control group, the difference between two groups was statistically significant (OR=2.11, 95%CI:1.59-2.81, P < 0.01).The incidence of adverse drug reactions (insomnia, extrapyramidal symptoms, akathisia) in traditional Chinese medicine combined with risperidone treatment group was lower than that in alone risperidone group, and there were significant differences between two groups (OR=0.25,95%CI:0.17-0.36, P < 0.01). Conclusion: Traditional Chinese medicine combined with risperidone is superior to simple application of risperidone in the treatment of schizophrenia, and they can reduce the occurrence of adverse effects of medicine.

Key words: schizophrenia, traditional Chinese medicine, risperidone, Meta-analysis, systematic review

中图分类号:

R749.3

陶茹莹, 李淼, 张辉. 中药联合利培酮治疗精神分裂症有效性及安全性的Meta分析[J]. 吉林大学学报(医学版), 2016, 42(04): 757-762.

TAO Ruying, LI Miao, ZHANG Hui. Meta-analysis on effectiveness and safety of traditional Chinese medicine combined with risperidone in treatment of schizophrenia[J]. Journal of Jilin University Medicine Edition, 2016, 42(04): 757-762.

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