不同体质量指数阿尔茨海默病患者PET/CT联合显像和IL-6水平及ApoE表达率检测及其临床意义

doi:10.13481/j.1671-587x.20170328

吉林大学学报(医学版) ›› 2017, Vol. 43 ›› Issue (03): 611-614.doi: 10.13481/j.1671-587x.20170328

不同体质量指数阿尔茨海默病患者PET/CT联合显像和IL-6水平及ApoE表达率检测及其临床意义

陆国秀¹, 张国旭¹, 郝珊瑚¹, 郭佳¹, 张文文¹, 张景华², 王治国¹

1. 沈阳军区总医院核医学科, 辽宁沈阳 110016;
2. 沈阳军区总医院神经内科, 辽宁沈阳 110016

收稿日期:2016-12-05 出版日期:2017-05-28 发布日期:2017-06-01
通讯作者: 王治国,副教授,硕士研究生导师(Tel:024-28851392,E-mail:wangzhiguo5778@163.com) E-mail:wangzhiguo5778@163.com
作者简介:陆国秀(1982-),女,辽宁省朝阳市人,主治医师,医学硕士,主要从事影像诊断与核素治疗方面的研究。
基金资助:
辽宁省自然科学基金资助课题（（2014020066）

PET/CT imaging and detection of levels of IL-6 and expression rates of ApoE in Alzheimer's disease patients with different body-mass indexes and their clinical significances

LU Guoxiu¹, ZHANG Guoxu¹, HAO Shanhu¹, GUO Jia¹, ZHANG Wenwen¹, ZHANG Jinghua², WANG Zhiguo¹

1. Department of Nuclear Medicine, General Hospital, Shenyang Military Command, Shenyang 110016, China;
2. Department of Neurology, General Hospital, Shenyang Military Command, Shenyang 110016, China

Received:2016-12-05 Online:2017-05-28 Published:2017-06-01

摘要/Abstract

摘要： 目的：检测不同体质量指数（BMI）阿尔茨海默病（AD）患者血清中白细胞介素6（IL-6）水平及载质蛋白E（ApoE）的表达，探讨¹¹碳-匹斯堡复合物（¹¹C-PIB）和¹⁸氟-脱氧葡萄糖（¹⁸F-FDG） PET/CT联合显像对AD的诊断价值。方法：58例AD患者依据BMI分为低体质量组（BMI <18.5kg·m^-2，n=18）、正常体质量组（18.5kg·m^-2≤BMI <24.9kg·m^-2，n=13）、超重组（24.9kg·m^-2≤BMI <29.9kg·m^-2，n=12）和肥胖组（BMI ≥29.9kg·m^-2，n=15）。比较¹¹C-PIB 和¹⁸F-FDG PET/CT脑显像诊断AD的灵敏度、特异度和准确率。检测各组患者ApoE等位基因（ε2、ε3及ε4）表达率和血清IL-6水平。BMI与ApoE等位基因表达率及血清IL-6水平的相关性分析采用Spearman相关分析。结果：¹⁸F-FDG联合¹¹C-PIBPET/CT显像对低体质量组AD患者的诊断灵敏度、特异度和准确率分别为87.5%、80.0%和84.6%，高于单独¹¹C-PIB（55.6%、50.0%和53.8%）或¹⁸F-FDG显像（42.9%、50.0%和46.2%）（P<0.05）；AD患者BMI与血清IL-6水平呈负相关关系（r=-0.407，P=0.002）；ApoE等位基因各亚型中，ε4表达率（60.3%）高于ε2（18.9%）和ε3（20.7%），但AD患者BMI与ApoE等位基因不同亚型表达率之间无相关性（ r=-0.028，P=0.833）。结论：¹¹C-PIB和¹⁸F-FDGPET/CT联合显像对AD患者具有较高的诊断价值；¹¹C-PIB 、¹⁸F-FDG 结合血清IL-6水平及BMI可以更好地诊断和评估AD。

关键词: 载质蛋白E, ¹⁸氟-脱氧葡萄糖, 体质量指数, 计算机断层扫描, 阿尔茨海默病, 正电子发射体层摄影技术, 白细胞介素6, ¹¹碳-匹斯堡复合物

Abstract: Objective: To detect the interleukin-6 (IL-6) levels and expressions of applipoprotein E (ApoE) in the Alzheimer's disease (AD) patients with different body-mass indexes (BMI), and to explore the diagnotic value of ¹¹Pittsburgh comound-B (¹¹C-PIB) combined with ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) PET/CT imaging in AD. Methods: A total of 58 AD patients were divided into four groups according to their BMI:low BMI group(BMI <18.5 kg·m^-2,n=18),normal BMI group(18.5 kg·m^-2 ≤ BMI <24.9 kg·m^-2,n=13),high BMI group(24.9 kg·m^-2 ≤ BMI <29.9 kg·m^-2,n=12)and obese group(BMI ≥ 29.9 kg·m^-2,n=15). All the patients underwent PET/CT imaging (¹¹C-PIB and ¹⁸F-FDG). The sensitivity,specificity and accuracy rate, the expression rates of ApoE (ε2, ε3, and ε4) and the levels of serum IL-6 were detected. The relationship between BMI and the expression rates of ApoE and the serum levels of IL-6 were analyzed by Spearman analysis. Results: The sensitivity, specificity, and accuracy rate of the patients in low BMI group diagnosed by ¹¹C-PIB and ¹⁸F-FDG PET/CT were 87.5%,80.0%, and 84.6%, which were higher than those diagnosed by ¹¹C-PIB (55.6%,50.0%, and 53.8%) or ¹⁸F-FDG (42.9%,50.0%, and 46.2%)alone (P<0.05). The serum levels of IL-6 and BMI of the AD patients had a negative correlation(r=-0.407,P=0.002).The expression rate of ApoE ε4 allelic gene(60.3%) of the AD patients was higher than those of ε2(18.9%) and ε3 allelic genes(20.7%), but there was no correlation between the BMI and the expression rates of different ApoE allelic genes of the AD patients(r=-0.028,P=0.833). Conclusion: ¹¹C-PIB and ¹⁸F-FDG PET/CT has a high diagnotic value in the AD patients. ¹¹C-PIB and ¹⁸F-FDG combinated with serum IL-6 level and BMI could diagnose and evaluate AD more exactly.

Key words: Alzheimer's disease, interleukin-6, positron emission tomography, ¹⁸F-fluorodeoxyglucose, ¹¹C pittsburgh compound-B, body mass index, applipoprotein E, computed tomography

中图分类号:

R741.04

陆国秀, 张国旭, 郝珊瑚, 郭佳, 张文文, 张景华, 王治国. 不同体质量指数阿尔茨海默病患者PET/CT联合显像和IL-6水平及ApoE表达率检测及其临床意义[J]. 吉林大学学报(医学版), 2017, 43(03): 611-614.

LU Guoxiu, ZHANG Guoxu, HAO Shanhu, GUO Jia, ZHANG Wenwen, ZHANG Jinghua, WANG Zhiguo. PET/CT imaging and detection of levels of IL-6 and expression rates of ApoE in Alzheimer's disease patients with different body-mass indexes and their clinical significances[J]. Journal of Jilin University Medicine Edition, 2017, 43(03): 611-614.

参考文献

[1] Duhois B,FeIdman HH,Jacova C,et al. Advancing research diagnostic criteria for AIzheimer's disease:The IWG-2 criteria[J].Lancet Neurol,2014,13(6):614-629.
[2] Chen CS,Ouyang P,Yeh YC,et al.Apolipopmtein E polymorphism and behavioral and psychological symptoms of dementia in patients with Alzheimer disease[J].Alzheimer Dis Assoc Disord,2012,26(2):135-139.
[3] 胥丽霞,王景涛.载脂蛋白E基因多态性与阿尔茨海默病精神行为症状的关系[J].中国老年学杂志,2016,36(10):2484-2486.
[4] Rasmussen L, Delabio R, Horiguchi L, et al. Association between interleukin 6 gene haplotype and Alzheimer's disease:a Brazilian case-control study[J]. J Alzheimers Dis,2013,36(4):733-738.
[5] Lainscak M, von Haehling S, Doehner W, et al. The obesity paradox in chronic disease:facts and numbers[J]. J Cachexia Sarcopenia Muscle, 2012, 3(1):1-4.
[6] Besser LM, Gill DP, Monsell SE, et al. Body mass index, weight change, and clinical progression in mild cognitive impairment and Alzheimer disease[J]. Alzheimer Dis Assoc Disord, 2014, 28(1):36-43.
[7] Toledo JB, Tpledo E, Michael MW, et al. Cardiovascular risk factors, cortisol, and amyloid-β deposition in Alzheimer's disease neuroimaging initiative[J].Alzheimers Dement,2012, 8(6):483-489.
[8] Berti V, Murray J, Davies M, et al. Nutrient patterns and brain biomarkers of Alzhemer's disease in cognitively normal individuals[J]. J Nutr Health Aging,2015,19(4):413-423.
[9] Vidoni ED, Townley RA, Honea RA, et al. Alzheimer disease biomarkers are associated with body mass index[J]. Neurology, 2011,77(21):1913-1920.
[10] Hixson JE,Vernier DT. Restriction isotyping of human apolipo protein E by gene amplification and cleavage with Hha Ⅰ[J].J Lipid Res,1990,31(3):545-548.
[11] Caroli AI, Prestia A, Chen K, et al.Summary metrics to assess Alzheimer disease-related hypometabolic pattern with ¹⁸F -FDG PET:head-to head comparison[J].J Nucl Med,2012,53(4):592-600.
[12] Shea YF, Joyce HA, Lee SC, et al. Impact of ¹⁸FDG PET and ¹¹C-PIB PET brain imaging on the diagnosis of Alzheimer's disease and other dementias in a regional memory clinic in Hong Kong[J].Hong Kong Med J, 2016,22(4):327-333.
[13] Kemppainen NM,Aalto S,Wilson IA,et al.Voxei-based analysis of PET amyloid ligand ¹¹C-PIB uptake in Aizheimer disease[J].Neurology,2006,67(9):1575-1580.
[14] Mintun MA,LaRessa GN,Sheline YI,et al.¹¹C-PIB in a nonde mented population potential antecedent nlarker of Alzheimer disease[J].Neurolagy,2006,67(3):446-452.
[15] David C, Hsu, Elizabeth C,et al.Lower late-life body-mass index is associated with higher cortical amyloid burden in clinically normal elderly[J]. J Alzheimers Dis, 2016, 53(3):1097-1105.
[16] Erta M, Quintana A, Hidalgo J. Inter leukin-6, a major cytokine in the central, nervous system[J]. Int J Biol Sci,2012,8(9):1254-1266.
[17] Chakrabarty P, Jansen West K, Beccard A, et al. Massive gliosis induced by inter leukin-6 suppressed abeta deposition in vivo:evidence against in flammation asadriving force for a myloid deposition[J]. FASEB J,2010,24(2):548-559.
[18] Cojocaru M, Miu G.Study of inter leukin-6 peoduction in Alzheimer's disease[J].Rom J Inter Med,2011,49(1):55-58.
[19] 唐丽娜,许小明,李艳红,等,炎症因子与阿尔茨海默病的相关性研究进展[J].中国老年学杂志,2016,36(17):4378-4380.
[20] Harold D, Abraham R, Hollingworth P,et al. Genome-wide association study identifies variants at CLU and PICALM as sociated with Alzheimer's disease[J]. Nat Genet,2009,41(10):1088-1093.
[18] HuangY,MuckeL.Alzheimer mechanisms and therapeutic strategies[J].Cell,2012,148(6):1204-1222.
[21] 郑磊,张凤春,李玉妹,等.APOEε4等位基因与尿AD7c-NTP联合检测在阿尔茨海默病早期诊断中的价值[J].中国老年学杂志,2016,36(12):2914-2916.
[22] 代学扬,蔡莉,王颖,等.动态增强CT与¹⁸F-FDGPET-CT对肝脏占位病变诊断价值的比较研究[J].中国实用内科杂志,2015,35(增1):103-104.

不同体质量指数阿尔茨海默病患者PET/CT联合显像和IL-6水平及ApoE表达率检测及其临床意义

PET/CT imaging and detection of levels of IL-6 and expression rates of ApoE in Alzheimer's disease patients with different body-mass indexes and their clinical significances

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