2型糖尿病患者认知功能障碍及其影响因素调查分析

doi:10.13481/j.1671-587x.20180243

吉林大学学报(医学版) ›› 2018, Vol. 44 ›› Issue (02): 431-437.doi: 10.13481/j.1671-587x.20180243

2型糖尿病患者认知功能障碍及其影响因素调查分析

李春花^1,2, 郭昕¹, 豆静¹, 丁铭宣¹, 姚燕¹, 张艳秋³

1. 吉林大学公共卫生学院流行病与卫生统计学教研室, 吉林长春 130021;
2. 吉林省人民医院内分泌科, 吉林长春 130021;
3. 吉林大学第二医院心血管内科, 吉林长春 130041

收稿日期:2017-07-03 出版日期:2018-03-28 发布日期:2018-03-30
通讯作者: 姚燕,副教授,硕士研究生导师(Tel:0431-85619451,E-mail:yaoyan@jlu.edu.cn);张艳秋,副主任医师(Tel:0431-88796598,E-mail:929050996@qq.com) E-mail:yaoyan@jlu.edu.cn;929050996@qq.com
作者简介:李春花(1978-),女,吉林省龙井市人,副主任医师,医学硕士,主要从事内分泌临床方向的研究。
基金资助:
国家自然科学基金青年基金资助课题（81300660）

Survey analysis on cognitive dysfunction in patients with type 2 diabetes mellitus and its influecing factors

LI Chunhua^1,2, GUO Xin¹, DOU Jing¹, DING Mingxuan¹, YAO Yan¹, ZHANG Yanqiu³

1. Department of Epidemiology and Health Statistics, School of Public Health, Jilin University, Changchun 130021, China;
2. Department of Endocrinology, Jilin Province People's Hospital, Changchun 130021, China;
3. Department of Cardiovascular Medicine, Second Hospital, Jilin University, Changchun 130041, China

Received:2017-07-03 Online:2018-03-28 Published:2018-03-30

摘要/Abstract

摘要： 目的：探讨2型糖尿病（T2DM）患者认知功能障碍现状、影响因素及其防治策略和措施，为预防糖尿病患者轻度认知障碍（MCI）的发生提供理论依据。方法：选择确诊并接受住院治疗、自愿参加调查的192例T2DM患者为研究对象。收集患者一般人口学特征、一般行为特征和临床指标资料。采用蒙特利尔认知评估（MoCA）量表筛查患者认知功能障碍现状，应用日常生活活动能力（ADL）量表评定患者的ADL。采用χ²检验、t检验以及秩和检验对不同特征的T2DM患者进行认知功能的比较，采用多因素Logistic回归模型分析T2DM患者MCI发生的独立影响因素。MoCA量表认知功能各模块与影响因素的关系采用相关性分析，以P<0.05为有统计学意义的界值。结果：192例T2DM患者接受问卷调查，根据MoCA量表认知功能障碍判别标准，MCI发生率为80.21%（154/192）。多因素Logistic分析，高年龄和低家庭人均月收入为T2DM患者发生MCI的相关危险因素（P<0.05）。MoCA量表认知功能评价各模块与影响因素相关分析，年龄与注意力相关性最强，呈负相关关系（r=-0.334，P<0.05）；家庭人均收入与视空间和执行能力相关性最强，呈正相关关系（r=0.323，P<0.05）。结论：T2DM患者MCI情况较为严重，患者年龄和家庭人均收入是影响T2DM患者认知功能的影响因素，主要影响其视空间、执行能力、注意力以及记忆功能。

关键词: 日常生活活动能力, 视空间, 2型糖尿病, 注意力, 执行能力, 认知功能障碍

Abstract: Objective:To explore the status,the risk factors and prevention strategies and measures of cognitive dysfunction in the patients with type 2 diabetes mellitus (T2DM), and the provide the theoretical basis for preventing the mild cognitive impairment (MCI) in the patients with diabetes mellitus. Methods: A total of 192 patients with T2DM who were diagnosed definitely and received hospitalization treatment and accepted the questionnaire willingly were selected as the subjects. The general demographic characteristics, general behavioral characteristics and clinical data were collected. Montreal Cognitive Assessment (MoCA) was used to screen the status of the patients with cognitive impairment, and Activities of Daily Living (ADL) assessment was used to assess the ADL of the patients. Chi-square test, t test and Wilcoxon test were performed to compare the congnitive function between the patients with different features. Multivariable Logistic regression model was used to find the independent influencing factors of MCI in the patients with T2DM. The correlation analysis was used to analyze the relationships between the each module of cognitive function of MoCA and the influencing factors. The P<0.05 was regarded as a statistically significant value. Results: There were 192 patients with T2DM accepted the questionnaire. According to the criteria for cognitive impairment in MoCA, 154 of the 192 subjects had MCI, and the incidence of MCI was 80.21% (154/192). Multivariate Logistic regression analysis showed that the elderly and low family per capita monthly income were the risk factors of MCI in the patients with T2DM (P<0.05). The results of correlation analysis between the various modules of MoCA and the influencing factors showed that the age was related strongly to the attention ability (r=-0.334, P<0.05); the family per capita monthly income was strongly related to the visual space ability and executive ability (r=0.322, P<0.05). Conclusion: The incidence of MCI in the patients with T2DM is serious. Age and the per capita monthly income of family are the important factors affecting the cognitive function of the patients with T2DM, which mainly affect the visual space ability, executive ability, attention ability, and memory function.

Key words: cognitive dysfunction, activities of daily living, attention ability, type 2 diabetes mellitus, visual space, executive ability

中图分类号:

R587.1

李春花, 郭昕, 豆静, 丁铭宣, 姚燕, 张艳秋. 2型糖尿病患者认知功能障碍及其影响因素调查分析[J]. 吉林大学学报(医学版), 2018, 44(02): 431-437.

LI Chunhua, GUO Xin, DOU Jing, DING Mingxuan, YAO Yan, ZHANG Yanqiu. Survey analysis on cognitive dysfunction in patients with type 2 diabetes mellitus and its influecing factors[J]. Journal of Jilin University Medicine Edition, 2018, 44(02): 431-437.

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2型糖尿病患者认知功能障碍及其影响因素调查分析

Survey analysis on cognitive dysfunction in patients with type 2 diabetes mellitus and its influecing factors

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