吉林大学学报(医学版) ›› 2013, Vol. 39 ›› Issue (3): 494-497.doi: 10.7694/jldxyxb20130314

• 基础研究 • 上一篇    下一篇

罗汉果提取物对运动疲劳小鼠的抗疲劳作用

张晓峰,刘大铎     

  1. 吉林师范大学体育学院体育教育教研室,吉林 四平136000
  • 收稿日期:2012-09-20 出版日期:2013-05-28 发布日期:2013-07-01
  • 通讯作者: 刘大铎(Tel:0434-3292037,E-mail:chinaboy20000@163.com) E-mail:chinaboy20000@163.com
  • 作者简介:张晓峰(1977-),男,吉林省四平市人,讲师,医学硕±,主 要从事运动人体科学方面研究。
  • 基金资助:

    吉林省科技厅自然科学基金资助课题(20070573)

Anti-fatigue effect of siraitia grosvenorii fruit extracts on mice with exercise  fatigue

ZHANG Xiao-feng,LIU Da-duo   

  1. Department of Physical Education,School of Physical Education,Jilin Normal
    University,Siping 136000,China
  • Received:2012-09-20 Online:2013-05-28 Published:2013-07-01

摘要: 目的:研究罗汉果提取物(SGFE)的抗运动疲劳作用,为SGFE的临床应用提供依据。方法:将144只雄性ICR小鼠随机分为对照组、SGFE低剂量组、SGFE中剂量组和SGFE高剂量组,每组36只。对照组小鼠每天口服1.0 mL生理盐水,其他3组小鼠每天给予1.0 mL SGFE(SGFE分别为100、200和400 mg?kg-1),所有小鼠每周进行3次持续15 min的被动游泳训练,持续28d。末次小鼠被动游泳实验后处死,采集血液、肝脏和腓肠肌分别检测小鼠血乳酸(BLA)、血尿素氮(BUN)、肝糖原和肌糖原浓度。结果:与对照组比较,SGFE低、中和高剂量3组小鼠的游泳力竭时间延长(P<0.05),但SGFE 3组间比较差异无统计学意义(P<0.05);SGFE低、中和高剂量组小鼠BLA浓度明显低于对照组(P<0.05),且随SGFE剂量增加有下降趋势;SGFE中剂量组和高剂量组小鼠BUN浓度明显低于对照组(P<0.05),但低剂量组小鼠BUN浓度与对照组比较差异无统计学意义。SGFE低、中和高剂量组小鼠肝糖原和肌糖原浓度明显高于对照组(P<0.05),且随着SGFE剂量的增加有升高趋势。结论:补充SGFE对运动疲劳小鼠有明显的抗疲劳功效。

关键词: 罗汉果提取物, 运动疲劳, 血乳酸, 血尿素氮, 小鼠, ICR

Abstract: Objective To discuss the anti-fatigue effects of siraitia grosvenorii fruit extracts (SGFE) on the mice with exercise fatigue and to provide basis for clinical application of SGFE. Methods 144 male ICR mice were randomly divided into control group(n=36),SGFE low dosage group(n=36),SGFE middle dosage group(n=36) and SGFE high dosage  group(n=36).The mice in control group were received an oral administration of physiological saline in a volume of 1.0 mL,and the mice in other three groups were received 1.0 mL of SGFE (100,200 and 400 mg?kg-1,once a day) for 28 d. All mice were forced to swim for 15 min each day. After 28 d,the blood,liver and gastrocnemius were collected after forced  swimming test,and the biochemical parameters related to fatigue,including blood lactic acid(BLA),blood urea nitrogen(BUN),liver glycogen,and muscle glycogen were measured.Results Compared with control group,the exhautive swimming time of the mice in SGFE  low,middle and high dosage  groups was prolonged(P<0.05),but there were no significant differences between SGFE low dosage,middle dosage and high dosage  groups (P>0.05);the levels  of BLA of mice in SGFE low dosage,middle dosage and high dosage  groups were significantly lower than that in control group(P<0.05),and the BLA levels showed  a decreasing trend with the  increase of SGFE  in SGFE  low,middle  and high dosage  groups.The levels of BUN  of mice in SGFE middle  and high dosage groups were significantly lower than that in control group (P<0.05),but there was no significantdifference between SGFE  low dosage group and control group.The levels of liver glycogen and muscle glycogen of mice in SGFE low,middle  and high dosage  groups were significantly higher than that in control group(P<0.05),and they showed a increasing trend with the increase of SGFE  dosagein   SGFE low,middle and high dosage groups. Conclusion SGFE  has significant anti-fatigue effect on the  mice with exercise fatigue.

Key words:  , siraitia grosvenorii fruit extracts, physical fatigue, blood lactic acid, blood urea nitrogen, mice,ICR

中图分类号: 

  • R962