前列舒通片对大鼠非细菌性前列腺炎炎症反应的抑制作用

doi:吉林省科技厅科技发展计划项目基金资助课题

前列舒通片对大鼠非细菌性前列腺炎炎症反应的抑制作用

林天慕¹，管清香²，李红³，杨世杰³，王恩思^1,2

1.吉林大学生命科学学院生物制药系，吉林长春 130021；2.吉林大学药学院天然药物化学教研室，吉林长春 130021；3.吉林大学基础医学院药理学教研室，吉林长春 130021

收稿日期:2007-05-31 修回日期:1900-01-01 出版日期:2008-07-28 发布日期:2008-07-28
通讯作者: 王恩思,杨世杰

Effects of Qianlie Shutong Tablets on inflammatory reaction of nonbacterial prostatitis in rats

LIN Tian-mu¹，GUAN Qing-xiang²，LI Hong³，YANG Shi-jie³，WANG En-si^1,2

1. Department of Biology Pharmacy,School of Life Science，Jilin University，Changchun 130012，China；2. Department of Natural Pharmaceutical Chemistry，School of Pharmacy，Jilin University,Changchun 130021，China;3. Department of Pharmacology,School of Basic Medical Sciences,Changchun 130021，China;

Received:2007-05-31 Revised:1900-01-01 Online:2008-07-28 Published:2008-07-28
Contact: Wang En-si,Yang Shi-jie

摘要/Abstract

摘要： 目的：观察前列舒通片（QLS）对非细菌性急、慢性前列腺炎模型中炎症反应的作用，为临床应用提供药效学依据。方法：Wistar大鼠按体重区组随机分组方法分为空白对照组、模型组、阳性对照组(前列康片组)及QLS低（17.5 mg•kg^-1）、中（35.0 mg•kg^-1）、高剂量组（70.0 mg•kg^-1），每组10只，分别于前列腺背叶的精囊腺注入1 %角叉菜胶生理盐水溶液，制作大鼠非细菌性前列腺炎模型，观察测定前列腺液中白细胞数和卵磷脂小体密度、前列腺重量、前列腺指数。在大鼠前列腺内注入消痔灵注射液制作非细菌性慢性前列腺炎模型，给药30 d后处死，观察前列腺组织形态学变化。结果：与模型组比较，QLS各给药组白细胞数不同程度减少。35.0和70.0 mg•kg^-1 QLS组前列腺液中白细胞数明显减少（P<0.05），卵磷脂小体密度显著增加（P<0.05或P<0.01）；17.5 mg•kg^-1 QLS组前列腺液中白细胞数减少、卵磷脂小体密度增加不明显。与模型组比较，70.0 mg•kg^-1 QLS组前列腺重量和前列腺指数明显减小、白细胞的浸润和纤维母细胞的增生减轻（P<0.05或P<0.01）；35.0 mg•kg^-1 QLS组前列腺指数明显降低（P<0.05），白细胞浸润减轻（P<0.01）。结论：QLS具有抑制大鼠非细菌性急、慢性前列腺炎炎症反应的作用。  

关键词: 前列腺炎, 药效学

Abstract: Objective To investigate the effects of Qianlie Shutong Tablets(QLS) on inflammatory reaction of nonbacterial acute and chronic prostatitis in rats and provide medical basis for its clinical use. Methods A total of 60 male rats were randomly assigned into normal group,model group,drug control group (Qianliekang group),low -dose(17.5 mg•kg^-1),mid-dose (35.0 mg•kg^-1) and high -dose QLS (70.0 mg•kg^-1) groups,10 rats in each group. White cell count,lecithin corpuscle density in prostatic fluid，prostate weight and prostate index were observed respectively after acute rat models were made by injecting 1 % carrageenan in th e seminal vesicle of prostate gland notopodium. The chronic prostatitis models were made by injecting hemorrhoid into prostate gland. The morphological changes of prostate tissue were observed 30 d after administration. Results Compared with model group,white cells in prostate fluid were obviously decreased (P<0.05) and lecithin corpuscle densities were obviously increased (P<0.05 or P<0.01) in 35.0 and 70.0 mg•kg^-1 QLS groups. However,QLS with the dose of 17.5 mg•kg^-1 did not obviously affect the number of white cells and lecithin corpuscle density. Compared with model group,QLS with the dose of 70.0 mg•kg^-1 significantly diminished prostate weight（P<0.05）and prostate index(P<0.01),as well as significantly inhibited infiltration of white cells(P<0.01)and fibroblast accrementition (P<0.05),which was similar with the positive Qianliekang group. QLS with the dose of 35.0 mg•kg^-1 significantly diminished prostate index(P<0.05) and inhibited infiltration of white cells(P<0.01). Conclusion QLS has inhibitory effects on inflammatory reaction of nonbacterial acute and chronic prostatitis.

Key words: prostatitis, pharmacodynamics

中图分类号:

R965

林天慕，管清香，李红，杨世杰，王恩思. 前列舒通片对大鼠非细菌性前列腺炎炎症反应的抑制作用[J]. J4, 2008, 34(4): 624-627.

LIN Tian-mu，GUAN Qing-xiang，LI Hong，YANG Shi-jie，WANG En-si. Effects of Qianlie Shutong Tablets on inflammatory reaction of nonbacterial prostatitis in rats[J]. J4, 2008, 34(4): 624-627.

[1]	刘莹瑞, 段立波. 地氟醚药理特性及其临床应用的研究进展[J]. 吉林大学学报(医学版), 2018, 44(02): 448-454.
[2]	张美双, 张宇, 任伯颖, 唐珊, 孙佳明, 张辉. 人参黄连组合物对糖尿病肾病小鼠的治疗作用[J]. 吉林大学学报(医学版), 2016, 42(06): 1104-1107.
[3]	卢凤迎，廖新红，李智贤，高泳,李天宇. 微血管密度在经直肠超声血流动力学检测鉴别诊断前列腺癌和慢性前列腺炎中的应用及其评价[J]. 吉林大学学报(医学版), 2014, 40(05): 1104-1108.
[4]	阮黎，华兴，李正明. VDR基因FokⅠ多态性与不同严重程度前列腺炎发生的关联性分析[J]. 吉林大学学报(医学版), 2013, 39(3): 570-573.
[5]	林天慕，李红，管清香，杨世杰，王恩思. 前列舒通片对鼠的抗炎及镇痛作用[J]. J4, 2008, 34(3): 453-457.
[6]	钟淑霞,李珊山,张朝英，赵翠扬，马蕾. 慢性非细菌性前列腺炎患者生殖支原体感染的检测及意义[J]. J4, 2006, 32(1): 125-3.