Journal of Jilin University(Medicine Edition) ›› 2021, Vol. 47 ›› Issue (2): 265-274.doi: 10.13481/j.1671-587X.20210203
• Research in basic medicine • Previous Articles Next Articles
Tianqi ZOU1,Lin BAI1,Zhengxu ZHANG1,He LI1,Chunmei WANG1,Jinghui SUN1,Jianguang CHEN1,Xi CHEN2(),Chengyi ZHANG1()
Received:
2020-07-30
Online:
2021-03-28
Published:
2021-03-25
Contact:
Xi CHEN,Chengyi ZHANG
E-mail:846617750@qq.com;zhchyjl@163.com
CLC Number:
Tianqi ZOU,Lin BAI,Zhengxu ZHANG,He LI,Chunmei WANG,Jinghui SUN,Jianguang CHEN,Xi CHEN,Chengyi ZHANG. Inhibitory effect of prunus tomentosa thunb total flavonoids on skin hypertrophic scar in mice and its mechanism[J].Journal of Jilin University(Medicine Edition), 2021, 47(2): 265-274.
Tab.2
Skin wound healing of mice in various groups (n=16,x±s,η/%)"
Group | Healing rate of wound | |||||
---|---|---|---|---|---|---|
(t/d) 4 | 7 | 10 | 13 | |||
Model control | 30.690±0.074 | 54.700±0.105 | 82.130±0.063 | 88.580±0.014 | ||
DXM | 41.660±0.050** | 60.300±0.105 | 66.650±0.044* | 70.020±0.042** | ||
PTTP | ||||||
Low dose | 37.930±0.043* | 62.270±0.066 | 87.020±0.039* | 90.330±0.019* | ||
Middle dose | 42.090±0.068* | 72.660±0.023* | 88.930±0.034* | 92.780±0.016* | ||
High dose | 39.100±0.046* | 64.540±0.150 | 88.220±0.040 | 92.550±0.011** | ||
Group | Healing rate of wound | |||||
(t/d) 16 | 19 | 22 | 25 | |||
Model control | 90.300±0.023 | 92.690±0.009 | 93.900±0.007 | 95.000±0.007 | ||
DXM | 81.730±0.001* | 87.030±0.007* | 88.650±0.010* | 90.170±0.007* | ||
PTTP | ||||||
Low dose | 92.910±0.016* | 94.650±0.014 | 95.730±0.014 | 96.540±0.009* | ||
Middle dose | 94.180±0.015* | 95.560±0.009** | 96.650±0.007* | 97.080±0.008* | ||
High dose | 93.470±0.011 | 95.100±0.013* | 95.940±0.012* | 96.780±0.012 | ||
Group | Healing rate of wound | |||||
(t/d) 28 | 31 | 34 | 37 | 40 | ||
Model control | 95.850±0.006 | 96.510±0.004 | 96.870±0.004 | 97.420±0.006 | 97.930±0.004 | |
DXM | 91.180±0.009* | 91.960±0.009* | 93.410±0.003** | 94.380±0.007* | 95.580±0.004* | |
PTTP | ||||||
Low dose | 97.000±0.007* | 97.570±0.006 | 97.950±0.005* | 98.550±0.003* | 98.940±0.002* | |
Middle dose | 97.500±0.005* | 98.040±0.002** | 98.560±0.002** | 98.900±0.001* | 99.140±0.002* | |
High dose | 97.230±0.009 | 97.960±0.004** | 98.310±0.002* | 98.730±0.002** | 99.040±0.002* |
1 | TAN W Q, FANG Q Q, SHEN X Z, et al. Angiotensin‐converting enzyme inhibitor works as a scar formation inhibitor by down‐regulating Smad and TGF‐β‐activated kinase 1 (TAK1) pathways in mice [J]. Br J Pharmacol, 2018, 175(22): 4239-4252. |
2 | ZHOU J ,ZHAO Y,SIMONENKO V, et al. Simultaneous silencing of TGF-β1 and COX-2 reduces human skin hypertrophic scar through activation of fibroblast apoptosis [J]. Oncotarget, 2017, 8(46): 80651-80665. |
3 | ZHOU Y, ZHAO Y, DU H, et al. Downregulation of CFTR is involved in the formation of hypertrophic scars [J]. Biomed Res Int,2020,2020:9526289. |
4 | ZHANG Y, SHAN S,WANG J, et al. Galangin inhibits hypertrophic scar formation via ALK5/Smad2/3 signaling pathway[J].Mol Cell Biochem,2016,413(1/2):109-118. |
5 | WANG H, GUO B, LIN S, et al. Apigenin inhibits growth and migration of fibroblasts by suppressing FAK signaling [J]. Aging(Albany NY), 2019, 11(11): 3668-3678. |
6 | 曹 爽, 范紫薇, 王映映, 等. 毛樱桃总黄酮对RAW264.7细胞中炎症因子水平的影响及其机制 [J]. 吉林大学学报(医学版), 2019, 45(4): 836-842. |
7 | BEER M F,FRANK F M,GERMĀN ELSO O, et al. Trypanocidal and leishmanicidal activities of flavonoids isolated from Stevia satureiifolia var. satureiifolia [J]. Pharm Biol, 2016, 54(10): 2188-2195. |
8 | 师继超, 赵东双, 刘圆圆, 等. 不同制备工艺所得毛樱桃总黄酮的抗炎活性研究 [J]. 北华大学学报(自然科学版), 2017, 18(3): 345-347. |
9 | PANG Y X, ZHANG Y,HUANG L Q, et al. Effects and mechanisms of total flavonoids from Blumea balsamifera (L.) DC. on skin wound in rats [J]. Int J Mol Sci, 2017,18(12): 2766-2767. |
10 | LV W F,DING M Y,ZHENG R. Isolation and quantitation of amygdalin in Apricot-kernel and Prunus Tomentosa Thunb. by HPLC with solid-phase extraction [J]. J Chromatogr Sci, 2005, 43(7): 383-387. |
11 | 穆 鑫. PLCε的缺陷延缓小鼠早期皮肤伤口愈合并减弱瘢痕形成 [D]. 天津:天津医科大学, 2017. |
12 | 赵冬双, 刘园园, 陈 曦, 等. 毛樱桃抗冻伤涂膜剂的制备及药效学研究 [J]. 中药材, 2018, 41(8): 1950-1953. |
13 | MA Y, LUO Y Q, SONG L, et al. Pharmaceutical screening of the effective fraction from Smilax for treatment of chronic pelvic inflammatory disease [J].Southern Med Univ, 2013, 33(1): 145-149. |
14 | ZHANG Y F, ZHOU S Z, CHENG X Y, et al. Baicalein attenuates hypertrophic scar formation via inhibition of the transforming growth factor-β/Smad2/3 signalling pathway [J]. Br J Dermatol, 2016, 174(1): 120-130. |
15 | SONG J, TRUONG D, YANG B. Quercetin shows the pharmacological activity to simultaneously downregulate the inflammatory and fibrotic responses to tissue injury in association with its ability to target multi-kinases [J]. Pharmacology, 2018, 102(3/4):142-153. |
16 | YANG L, LI X, ZHANG S, et al. Baicalein inhibits proliferation and collagen synthesis of mice fibroblast cell line NIH/3T3 by regulation of miR-9/insulin-like growth factor-1 axis [J]. Artif Cells Nanomed Birtechnol, 2019, 47(1): 3202-3211. |
17 | ZHANG M Z,DONG X H, GUAN E L, et al. A comparison of apoptosis levels in keloid tissue, physiological scars and normal skin [J]. Am J Transl Res, 2017, 9(12): 5548-5557. |
18 | SAFAEIAN L, ABED A, VASEGHI G. The role of Bcl-2 family proteins in pulmonary fibrosis [J]. Eur J Pharmacol, 2014, 74:281-289. |
19 | JIAN X Q,QU L,WANG Y L, et al. Trichostatin A-induced miR-30a-5p regulates apoptosis and proliferation of keloid fibroblasts via targeting BCL2[J]. Mol Med Rep, 2019,19(6):5251-5262. |
20 | 周 曙, 田 芳, 金海蓉,等. 姜黄素调节Bcl-2、Bax蛋白表达诱导增生性瘢痕成纤维细胞凋亡 [J]. 湖南中医药大学学报, 2015, 35(4): 6-9. |
21 | GONG Y F, ZHANG X M, YU J, et al. Effect of recombinant human endostatin on hypertrophic scar fibroblast apoptosis in a rabbit ear model [J]. Biomed Pharmacother, 2017, 91:680-686. |
[1] | Xue LUAN,Guanghai YAN,Haibo LI,Bo ZHANG,Wei ZHANG,Yuanyuan HUANG. Effect of salidroside on airway inflammation in mice with asthma and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2021, 47(3): 537-544. |
[2] | Cuilan LIU,Jianjun LI,He JIANG,Jing LIU,Dan WANG,Chen LI,Di ZHAO. Effect of urolithin B on biological behaviors of human glioblastome U118 MG cells and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2021, 47(3): 566-574. |
[3] | Jia FENG,Haichan XU,Jian WEN,Zehua WU,Yi CHEN. Effect of betulinic acid on proliferation and apoptosis of myeloma cells by regulating JAK2/STAT3 signaling pathway and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2021, 47(3): 615-622. |
[4] | Pei GONG,Jingran LIU,Shimin ZHAO,Yuzhen WANG,Jiming XIE. Inhibitory effect of MCM10 silencing on proliferation of breast cancer MDA-MB-231 cells and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2021, 47(3): 652-659. |
[5] | Xiaohui LI,Ziwei QU,Xin LU,Qingbin MENG,Huatao CHEN,Jun REN,Chengpei TAN. Regulatory effect of exosomes carrying miR-196b-5p derived from bone marrow mesenchymal stem cells on biological characteristics of colon cancer cells [J]. Journal of Jilin University(Medicine Edition), 2021, 47(3): 660-668. |
[6] | Bingxue QI,Yan MA,Yixian ZHANG,Yadong SUN,Lining MIAO. Effect of liraglutide on expressions of mRNA and protein of related proteins after podocyte injury induced by high glucose and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2021, 47(2): 275-283. |
[7] | Zhanqi ZHAO,Chengjin ZHANG,Juan TIAN. Inhibitory effect of Ndfip1 on ferrion-induced neuronal apoptosis and its neuroprotective mechanism [J]. Journal of Jilin University(Medicine Edition), 2021, 47(2): 338-343. |
[8] | Haoxuan TANG,Nanfeng MENG,Meiling DU,Wei WANG,Tao HE. Inhibitory effect of new VEGF monoclonal antibody combined with all-trans retinoic acid on proliferation of breast cancer MCF-7 cells [J]. Journal of Jilin University(Medicine Edition), 2021, 47(2): 344-351. |
[9] | Jie WU,Xuehua YANG,Ling MA,Wenqiang FAN,Dongdong FU,Xiao GAO,Shufei ZUO,Shu LIANG,Yilu QIN,Peishan WANG,Jinyan GUO. Effect of miR-26a-5p on apoptosis of human rheumatoid arthritis fibroblast-like synovial cells through JAK2/STAT3 signaling pathway [J]. Journal of Jilin University(Medicine Edition), 2021, 47(2): 460-468. |
[10] | Haiying ZHANG,Wenxin ZHANG,Wenjing ZHAO,Wei LI. Induction effect of gallic acid on apoptosis of human hepatocellular carcinoma HepG-2 cells through regulating mitochondrial oxidative phosphorylation [J]. Journal of Jilin University(Medicine Edition), 2021, 47(1): 125-132. |
[11] | . Inhibitory effect of curcumin on tumor growth in colorectal cancer mice and its mechanism of PTEN/PI3K/Akt signaling pathwayPEI Yongbin, WANG Guiqi, LI Wei, JIANG Xia, JIANG Haibo, ZHAO Zengren (Department of General Surgery,First Hospital,Hebei Medical University, Shijiazhuang 050031,China) [J]. Journal of Jilin University(Medicine Edition), 2021, 47(1): 145-151. |
[12] | LI Qi, XU Rui, LI Tengteng, JIANG Yichuan, LI Min. Effect of pirarubicin on cardiomyocyte injury in rats and establishment of its model [J]. Journal of Jilin University(Medicine Edition), 2020, 46(05): 948-954. |
[13] | LI Wei, ZHANG Haifeng, WANG Miao, HUO Jing, ZHANG Ying, ZHAO Cui. Protective effect of Astragalus Injection on heart of rats with sleep deprivation and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2020, 46(05): 998-1003. |
[14] | JIA Daqi, KONG Wencong, SU Rongjian, DU Xiaoyuan, HE Wubin. Effects of macrophage stimulating 1 receptor inhibitor BMS777607 on proliferation and apoptosis of lung cancer cells [J]. Journal of Jilin University(Medicine Edition), 2020, 46(04): 739-744. |
[15] | ZHANG Shuangshuang, HE Wubin, SU Rongjian, DU Xiaoyuan. Effects of EZH2 inhibitor GSK126 on proliferation and apoptosis of lung adenocarcinoma cells [J]. Journal of Jilin University(Medicine Edition), 2020, 46(04): 786-791. |