The information of overnight polysomnography parameters of 106 OSA patients were collected，including sleep parameters and respiratory event parameters，as well as non-invasive multi-point continuous blood pressure monitoring during wakefulness and sleep stages on the monitoring day. The speed of deoxygenation was calculated by the ratio of the latitude value for oxygen desaturation and correspondent duration of desaturation. The reoxygenation speed was calculated similarly. The patients were divided into two groups based on the blood pressure values： OSA complicated with hypertension group （OSA+HT，n=59） and OSA without hypertension group（OSA－HT，n=47）. The differences in the speeds of deoxygenation and reoxygenation were analyzed between two groups.The correlations were respectively analyzed between the speeds of deoxygenation，reoxygenation， the diurnal and nocturnal blood pressure and the nocturnal blood pressure fluctuation（NBPF） for all the OSA patients.

The deoxygenation speed and the reoxygenation speed in OSA + HT group was significantly higher than that in OSA－HT group （P<0.01）；the deoxygenation speed was positively correlated with the nocturnal systolic blood pressure， diastolic blood pressure， mean arterial pressure， diurnal diastolic blood pressure and mean arterial pressure （r=0.311，P=0.001；r=0.245， P= 0.011；r=0.308， P=0.001；r=0.203，P=0.037；r=0.219，P=0.024）， and the reoxygenation speed was positively correlated with the nocturnal systolic blood pressure， diastolic blood pressure， mean arterial pressure，diurnal diastolic blood pressure and mean arterial pressure （r=0.327，P=0.001；r=0.288，P=0.003；r=0.343，P=0.000；r=0.250，P=0.01；r=0.259，P=0.007）； there was a positive correlation between both of the deoxygenation speed and the reoxygenation speed and NBPF（r=0.595，P<0.01；r=0.646， P=<0.01）.

The damage of deoxygenation and reoxygenation in the OSA patients is directly related to the increase of blood pressure both during wakefulness and sleep stages. The changes of deoxygenation and reoxygenation speeds are the important factors for NBPF in the OSA patients.