A total of 70 healthy SD rats were randomly divided into blank control group （n=10） and right eye suture group （n=60）.The rats in right eye suture group were used to establish the visual deprivation models by right eye suture.Then the successful model rats were randomly divided into model group， levodopa methyl ester （LDME） group and early（3 d after model replication）， middle（12 d after model replication） and late（21 d after model replication） acupuncture groups（n=10）. After the corresponding intervention， the concentrations of oxyhemoglobin（Oxy-Hb）， deoxygenated hemoglobin（Deoxy-Hb） and total hemoglobin（Total-Hb） of the rats in various groups were detected by functional near infrared spectroscope （fNIRs） technique.

Compared with blank control group， the concentrations of Oxy-Hb in bilateral visual cortex of 2-5 and 4-4 channels of the rats in model group were significantly decreased （P<0.05）； compared with model group，the concentrations of Oxy-Hb and Total-Hb in 2-5 and 4-4 channels in early， middle and late acupuncture groups were significantly increased （P<0.05）；the concentrations of Deoxy-Hb were decreased； there were no significant differences in the concentrations of Oxy-Hb， Deoxy-Hb and Total-Hb between the left and right sides of 2-5 and 4-4 channels in blank control group （P>0.05）， but the concentration of Oxy-Hb in the right side of the rats in model group was higher than that in the left side （P<0.01）. In LDME group， the concentrations of Oxy-Hb and Deoxy-Hb in the right side was higher than that in the left side （P<0.05）， but there was no difference in the concentration of Total-Hb （P>0.05）. In early acupuncture group， the Oxy-Hb concentration of rats had no difference between the left and right sides （P>0.05）， while the concentrations of Deoxy-Hb and Total-Hb in the right side were higher than those in the left side （P<0.05）. In middle and late acupuncture groups， the concentrations of Oxy-Hb， Deoxy-Hb and Total-Hb of rats in the right side were higher than those in the left side （P<0.05）.

After monocular （right） visual deprivation， the sensitivity and selectivity of orientation information perception of neurons in the ipsilateral visual cortex are significantly inhibited， and the function of orientation column in the ipsilateral visual cortex is abnormal. Early acupuncture can effectively regulate the “drift” and abnormal reorganization of visual cortex orientation column after visual deprivation.