The human neuroblastoma SH-SY5Y cells were given different concentrations（0，0.25，0.50，1.00，and 2.00 mmol·L^－1）MMP⁺，and the survival rates of the SH-SY5Y cells were detected after 24 and 48 h.The experiment was divided into control group［given phosphate buffered saline（PBS）］， 0.50 mmol·L^－1 MPP⁺ group （given 0.50 mmol·L^－1 MPP⁺），MPP⁺+BMSCs supernatnt （BMSCs-Sup）group （given 0.50 mmol·L^－1 MPP⁺+BMSCs-Sup），0.50 mmol·L^－1 MPP⁺+BMSCs-Exo group （given 0.50 mmol·L^－1 MPP⁺ +100 mg·L^－1 BMSCs-Exo），MPP⁺ +rapamycin（Rap） group （given 0.50 mmol·L^－1 MPP⁺ +2 mmol·L^－1 Rap） and MPP⁺ +BMSCs-Exo+3-methyladenine（3-MA） group（given 0.50 mmol·L^－1 MPP⁺ +100 mg·L^－1 BMSCs-Exo +1 mmol·L^－1 3-MA）. The survival rates of the SH-SY5Y cells in various groups were detected by MTT assay.The fluorescence intensities of autophagic acid vesicles in the SH-SY5Y cells in various groups were detected by acridine orange staining under confocal microscope.The expression levels of CD63， TGS101，and Calnexin proteins in the SH-SY5Y cells in various groups were detected by Western blotting method.

The MTT assay results showed that the survival rates of the SH-SY5Y cells were decreased gradually with the increasing of the MPP⁺ concentration or the extension of treatment time （P<0.05） in a concentration- and time-dependent manner. Compared with MPP⁺ group， the survival rates of the SH-SY5Y cells in MPP⁺ + BMSCs-Sup group， MPP⁺ +BMSCs-Exo group，and MPP⁺ + Rap group were increased （P<0.05）. Compared with MPP⁺ +BMSCs-Exo group， the survival rate of the SH-SY5Y cells in MPP⁺ +BMSCs-Exo + 3-MA group was decreased （P<0.05）.The acridine orange staining results showed that compared with control group， the fluorescence intensities of autophagic acid vesicles in the SH-SY5Y cells in MPP⁺ + BMSCs-Sup group， MPP⁺ +BMSCs-Exo group and MPP⁺ + Rap group were increased （P<0.05）； compared with MPP⁺ +BMSCs-Exo group， the fluorescence intensity of autophagic acid vesicles in the SH-SY5Y cells in MPP⁺ +BMSCs-Exo + 3-MA group was decreased （P<0.05）.The Western blotting results showed that the exosome marker proteins CD63 and TGS101 were highly expressed， while the endoplasmic reticulum marker protein Calnexin was lowly expressed.

BMSCs-Exo can resist the MPP⁺-induced decreasing of the survival of the SH-SY5Y cells by activating the autophagy.