皮肤常驻记忆性T细胞对白癜风发生发展及复发影响的研究进展

doi:10.13481/j.1671-587X.20250533

Abstract

Abstract:

The cutaneous resident memory T cells （T_RM） are important immune surveillance cells in skin tissue and are highly heterogeneous. The T_RM achieve residency in skin by expressing residency markers such as CD69 and CD103， and their development and survival are regulated by several molecules such as interleukin-15 （IL-15）. In addition to their roles in infection and tumors， the T_RM， especially CD8+T_RM， play an important role in the development and recurrence of autoimmune skin diseases such as vitiligo. Under the continuous stimulation of melanocyte antigens， melanocyte-specific CD49a+T_RM1 can directly kill the melanocytes by expressing the interferon-γ（IFN-γ）， granzyme B and perforin and they also recruit circulating memory CD8+T cells through the IFN-γ-Janus kinase（JAK）-signal transducer and activator of transcription（STAT）（IFN-γ-JAK-STAT） signaling pathway to collectively kill the melanocytes， which promotes vitiligo development and recurrence. Combined with the research progress at home and abroad， this article now summarizes the source， function and biological properties of cutaneous T_RM， provides an overview of the research on T_RM in vitiligo development and recurrence， and elaborates on the strategy of intervening in the recurrence of vitiligo by targeting T_RM， aiming to provide the new ideas for the pathogenesis research and precise treatment of vitiligo.

Key words: Tissue-resident memory T cells, Vitiligo, Recurrence, Autoimmunity, Janus kinase, Signal transducer and activator of transcription

CLC Number:

R758.41

Huan WANG,Yu ZHEN,Shanshan LI. Research progress in effect of cutaneous tissue-resident memory T cells on development and recurrence of vitiligo[J].Journal of Jilin University(Medicine Edition), 2025, 51(5): 1429-1436.

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Research progress in effect of cutaneous tissue-resident memory T cells on development and recurrence of vitiligo

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