泛免疫炎症指数对老年冠心病患者PCI术后1年内主要心血管不良事件的预测价值

doi:10.13481/j.1671-587X.20250621

Abstract

Abstract:

Objective To discuss the clinical value of pan-immune inflammation index （PIV） in predicting the major adverse cardiovascular events （MACE） within 1 year after percutaneous coronary intervention （PCI） in the elderly patients with coronary heart disease， and to clarify the role of inflammatory response in postoperative recovery and prognosis of the patients with coronary heart disease. Methods A total of 150 elderly patients with coronary heart disease who underwent PCI from July 2020 to August 2023 were selected as the research subjects； according to the occurrence of MACE within 1 year after operation， they were divided into MACE group （n=28） and non-MACE group （n=122）； the baseline data and biochemical indicators of the patients were collected， and PIV was calculated； multivariate Logistic regression was used to analyze the influencing factors of MACE within 1 year after PCI in the elderly patients with coronary heart disease； receiver operating characteristic （ROC） curve was used to analyze the predictive value of PIV for MACE within 1 year after PCI in the elderly patients with coronary heart disease. Results Compared with non-MACE group， the levels of total cholesterol （TC） and low-density lipoprotein cholesterol （LDL-C）， neutrophils （NEUT）， platelets （PLT） counting and PIV in the patients in MACE group were significantly increased （P<0.05）； there were no significant differences in other data between two groups （P>0.05）. The multivariate Logistic regression analysis results showed that the levels of TC （OR=1.571， 95%CI： 1.088-2.270） and LDL-C （OR=32.506， 95%CI： 8.880-118.994） and PIV （OR=1.014， 95%CI： 1.010-1.019） were the influencing factors of MACE within 1 year after PCI in the elderly patients with coronary heart disease （P<0.05）. The ROC curve analysis results showed that the area under the ROC curve （AUC） of PIV for predicting MACE was 0.857 （95%CI： 0.762-0.951）， the sensitivity was 0.821， the specificity was 0.959， the maximum Youden index was 0.780， and the best cut-off value was 778.805 （P<0.01）. Conclusion PIV has important predictive value for MACE within 1 year after PCI in elderly patients with coronary heart disease.

Key words: Coronary heart disease, Pan-immune inflammation index, Major adverse cardiovascular events, Percutaneous coronary intervention, Elderly

CLC Number:

R541.4

Tao SUN,Zhiyin DAI,Xuan LI,Chaopu ZHANG,Shu DING,Jianwei ZHAO. Predictive value of pan-immune-inflammation index for major adverse cardiovascular events within 1 year after PCI in elderly patients with coronary heart disease[J].Journal of Jilin University(Medicine Edition), 2025, 51(6): 1655-1660.

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References 19

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Group	n	Gender（Male/Female）	Age (year)（x±s）	BMI（kg·m^-2）（x±s）	Hypertension[n（η/%）]	Diabetes mellitus[n（η/%）]	High blood lipids[n（η/%）]
Non-MACE	122	97/25	73.11±1.15	24.73±2.11	76（62.30）	45（36.89）	21（17.21）
MACE	28	20/8	72.75±1.08	24.82±2.05	17（60.71）	9（32.14）	3（10.71）
t/χ²		0.866	1.510	0.205	0.024	0.222	0.716
P		0.352	0.133	0.838	0.876	0.637	0.398

Independent variable	B	SE	Wald χ²	P	OR	95%CI
TC	0.452	0.188	5.805	0.016	1.571	1.088-2.270
LDL	3.481	0.662	27.650	<0.001	32.506	8.880-118.994
PIV	0.014	0.002	46.217	<0.001	1.014	1.010-1.019

Predictive value of pan-immune-inflammation index for major adverse cardiovascular events within 1 year after PCI in elderly patients with coronary heart disease

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