灯盏花素和丹参注射液治疗冠心病心绞痛患者有效性及安全性的Meta分析

doi:10.13481/j.1671-587x.20170220

Abstract

Abstract: Objective: To compare the effectiveness and safety of Dengzhanhuasu and Danshen Injection in the treatment of the patients with angina pectoris of coronary heart disease with Meta-analysis, and to provide basis for their application in clinic. Methods: Computer search was performed using Cochrane Central Register of Controlled Trial,Ovid-medline,EMBASE,PubMed,CNKI,Wanfang,VIP and CBM,and the literatures about the effectiveness and safety of Dengzhanhuasu and Dansheng Injection in the treatment of the patients with angina pectonis of coronary heart disease were obtained. According to the principle of selection and elimination, the literatures were selected, and the qualities of literatures were evaluated. The related data were extracted from the literatures.RevMan 5.3 software was used to extract the data for Meta-analysis. Results: A total of 167 literatures were retrieved, and 8 randomlized-controlled studies were selected according to the selection criteria. The evaluation results of the effectiveness of angina pectoris according to symptom showed that χ²=2.62,df=7,P=0.92,Z=6.85 (P<0.000 01), 95%CI:2.73-6.10. The evaluation of the effectiveness of angina pectoris according to electrocardiogram,χ²=6.37,df=7,P=0.50,Z=6.37(P=0.000 01),95%CI:1.94-3.49.The results of Meta-analysis showed that there were significant differences in the relief of symptoms and improvement of the electrocardiogram efficacy between Dengzhanhuasu and Danshen Injection in the treatment of angina pectoris of coronary heart disease (P<0.05). Conclusion: Dengzhanhuasu has better effectiveness in the treatment of the patients with unstable angina than Dansheng Injection and they have the same safety.

Key words: angina pectoris, Dengzhanhuasu Injection, Danshen Injection, Meta-analysis, coronary heart disease

CLC Number:

R541.4

ZHANG Yang, WANG Junfeng, CAOHongyan, QIN Ling, XU Guoliang. Effectiveness and safety of Dengzhanhuasu and Dansheng Injection in treatment of patients with angina pectoris of coronary heart disease:A Meta-analysis[J].Journal of Jilin University Medicine Edition, 2017, 43(02): 317-321.

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Effectiveness and safety of Dengzhanhuasu and Dansheng Injection in treatment of patients with angina pectoris of coronary heart disease:A Meta-analysis

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