乳腺癌组织中信号传导和转录激活因子1的表达及其与预后的关系

doi:10.13481/j.1671-587x.20150527

Abstract

Abstract:

Objective To explore the expression of signal transducers and activators of transcription 1(STAT1) in breast cancer tissue,and to investigate the relationship between the expression of STAT1 and prognosis of breast cancer. Methods The expressions of STAT1 in tumor tissue of 37 cases of benign breast tumor and 87 cases of breast cancer patients were detected by immunohistochemical technique.The associations between the expression of STAT1 and clinical parameters and prognosis were analyzed.Kaplan-Merier analysis and Log-rank test were used to conduct the overall survival(OS) analysis and draw the survival curve and detect the differences between survival curves. Results The strongly positive expression rate of STAT1 in breast cancer tissue was lower than that in benign tissue(P<0.01).The breast cancer patients with positive progesterone receptor(PR) had a higher expression of STAT1 compared with the breast cancer patients with negtive PR (P<0.05).The OS of the patients with high expression of STAT1 was longer than that of the patients with low expression of STAT1(P=0.044);the disease-free survival (DFS) of the patients with strongly positive expression of STAT1 was longer than that of the patients with lowly positive expression of STAT1,but there was no significant difference between them(P=0.071).The single factor analysis results showed that the endocrine therapy or not,expression of STAT1,hormone receptor status,and Her-2 expression were the influencing factors of OS;the TNM stage,endocrine therapy or not,hormone receptor status,and Her-2 expression were the influencing factors of DFS.The multifactor analysis results demonstrated that the endocrine therapy or not and expression of PR were the independent factors influencing OS;the TNM stage,endocrine therapy or not,expression of PR,and Her-2 expression were the independent factors influencing DFS. Conclusion The expression of STAT1 is higher in the breast cancer tissue with positive PR,and the expression of STAT1 may have a positive influence in the prognosis of breast cancer.

Key words: breast neoplasms, signal transducers and activators of transcription 1, progesterone receptor, prognosis

CLC Number:

R737.9

LIU Yuxin, WU Di, FU Tong, ZHAO Gang, FU Jing, SONG Dong. Expression of signal transducers and activators of transcription 1 in breast cancer tissue and its relationship with prognosis[J].Journal of Jilin University Medicine Edition, 2015, 41(05): 1012-1017.

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Expression of signal transducers and activators of transcription 1 in breast cancer tissue and its relationship with prognosis

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