血清半乳糖凝集素3水平与慢性心力衰竭及其预后关系的Meta分析

doi:10.13481/j.1671-587x.20150624

Abstract

Abstract:

Objective To evaluate the relationship between the newly recominended chronic heart failue(CHF) marker-serum galection-3(Gal-3) level and the prognosis of CHF by Meta-analysis. Methods The Chinese and English literatures about the relationship between Gal-3 and CHF prognosis were searched in PubMed,EMbase,Chinese Biomedical Literature Databases.All literatures were assessed by the inclusion and exclusion criteria.Hazard ratio (HR) and 95% confidence interval (CI) in each literature were extracted for Meta-analysis using STATA 12.1 software.The stability and reliability were evaluated by sensitivity analysis and publication bias analysis. Results Ten literatures complying with the requirements were included.The results of heterogeneity test were as follows: ① When the influence of other factors were not excluded, heterogeneity test showed that P=0.000, I²=89.2%, heterogeneity existed in different studies, so statistics were combined using a random effects model. The combined HR of univariate analysis was 1.36 and 95% CI was 1.23-1.50. 2. When the influence of other factors were excluded, heterogeneity test showed that P<0.001,I²=68.4%, heterogeneity existed in different studies, so statistics were combined using a random effects model. The combined HR of multivariate analysis was 1.17 and 95% CI was 1.07-1.26. 3. Sensitivity analysis showed that when the study with the largest samples was excluded, the combined HR of univariate analysis was 1.54 and 95% CI was 1.32-1.77; the combined HR of multivariate analysis was 1.26 and 95% CI was 1.09-1.42. When the study with the smallest samples was excluded, the combined HR of univariate analysis was 1.34 and 95% CI was 1.20-1.47; the combined HR of multivariate analysis was 1.15 and 95% CI was 1.06-1.24. Conclusion The serum level of Gal-3 is increased significantly in the patients with CHF and it may be an independent risk factor for poor prognosis of the CHF patients.

Key words: chronic heart failure, galectin 3, all cause mortality, Meta-analysis

CLC Number:

R541.4

YU Xiaoling, LIU Zhenjiang, QIN Ling. Relationship between serum levels of galectin-3 and prognosis of patients with chronic heart failure:A Meta-analysis[J].Journal of Jilin University Medicine Edition, 2015, 41(06): 1224-1229.

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Relationship between serum levels of galectin-3 and prognosis of patients with chronic heart failure:A Meta-analysis

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