Abstract: Objective: To explore the efficacy of Huaiqihuang Granules in the treatment of the children with asthma at non-acute attack stage and its effect on the immune function indexes of body. Methods: A total of 180 children with asthma at non-acute attack stage were divided into Huaiqihuang Granules treatment group (n=92,treated with traditional Chinese medicine Huaiqihuang Granules along with oral montelukast and inhaled corticosteroid,ICS+MK+Hgroup) and routine treatment group(n=88,only given oral montelukast and inhaled corticosteroid,ICS+MK group).The indexes of asthma attack degrees,traditional Chinese medicine (TCM) syndrome indexes, blood immune function indexes and pulmonary function indexes of the children in two groups were detected. Results: There was no difference in the disease degrees of the children between two groups before treatment(P>0.05).Compared with routine treatment group,the score of acute attack of asthma of the children in Huaihuang Granules treatment group was decreased after treatment(P<0.05).Compared with routine treatment group,the scores of dry/loose stools,low-grade fever,cough/expectoration, spiritlessness/anorexia and white tongue fur of the children in Huaiqihuang Granules treatment group were significantly decreased (P<0.01),and the scores of perspire during sleep and dry mouth with desire for drinking were decreased(P<0.05).Compared with routine treatment group,the levels of immunoglobulins (serum lgA,lgG and lgM) of the children in Huaiqihuang Granules treatment group were increased after treatment(P<0.05)Compared with routine treatment group,the percentages of T cells,Th cells and NK cells of the children in Huaiqihuang Granules treatment group were increased(P<0.05),the percentage of B cells was decreased(P<0.05),and there was no difference in the percentages of serum Ts cells of the children between two groups(P>0.05).Compared with routine treatment group,the peak expiratory flow (PEF) and the ratio value of forced expiratory volume in the first second/forced vital capacity(FEV1/FVC) of the children in Huaiqihuang Granules treatment group were increased (P<0.05),but there was no difference in FEV1 of the children between two groups(P>0.05). Conclusion: On the basis of routine treatment,Huaiqihuang Granules can reduce the condition of children with asthma at non-acute attack stage and improve the TCM syndrome and immune function.

Key words: Huaiqihuang Granules, asthma, children, immunoregulation, traditional Chinese medicine syndrome