姜黄素对骨质疏松大鼠种植体骨结合的促进作用

doi:10.13481/j.1671-587x.20190423

Abstract

Abstract: Objective:To investigate the effect of curcumin on the implant osseointegration in the rats with osteoporosis, and to clarify its mechanism. Methods:A total of 45 rats were randomly divided into control group (screw implant), model group (osteoporosis model + screw implant) and curcumin group (osteoporosis model + screw implant + curcumin treatment), with 15 rats in each group. The micro-CT was used to examine the relative bone volume fraction (BV/TV), average bone trabecular thickness (Tb. Th), trabecular space (Tb.Sp), average bone trabecular number (Tb.N),osseointegration index(OI) of the bone tissue around the implants of the rats in various groups; methylene blue-basic fuchsin staining was used to examine the morphology of bone tissue;the bone contact rate and the bone mass in cancellous bone area were calculated. The torque tester was used to measure the implant dislocation torque. Results:Compared with control group, the BV/TV, Tb.Th, Tb.N, OI,the bone contact rates,the bone mass in cancellous bone area,and the dislocation torque of bone interface around the implants of the rats in model group and curcumin group were significantly decreased (P<0.01), while Tb.Sp in model group and curcumin group were significantly increased (P<0.01). Compared with model group, the BV/TV, Tb.Th, Tb.N, OI, the bone contact rate, the bone mass in cancellous bone area,and the dislocation torque of bone interface around the implants of the rats in curcumin group were increased (P<0.01),while Tb.Sp was significantly decreased (P<0.01). In control group, the bonding of implant and bone was close, and the bone plate and trabeculae at the bonding interface of implant and bone were thicker and denser. In model group, the bone plate at the bonding interface of implant and bone was thin and the trabecular bone was sparse. In curcumin group, the bone plate and trabeculae at bonding interface of the implant and bone of the rats were thicker and denser. Conclusion:Curcumin can promote the implant healing, improve the implant and bone bonding strength and increase the implant stability in the osteoporosis rats.

Key words: curcumin, osteoporosis, implant, osseointegration, rats

CLC Number:

R285.5

XU Dongliang, PENG Zhaohui, XIONG Meicai. Promotion effect of curcumin on implant osseointegration in osteoporosis rats[J].Journal of Jilin University(Medicine Edition), 2019, 45(04): 877-881.

References

[1] CAI J, LI W, SUN T,et al.Pulsed electromagnetic fields preserve bone architecture and mechanical properties and stimulate porousimplantosseointegrationby promoting bone anabolism in type 1 diabetic rabbits[J].Osteoporos Int,2018,29(5):1177-1191.
[2] DUAN Y, MA W, LI D,et al.Enhancedosseointegration of titanium implants in a rat model of osteoporosis using multilayer bone mesenchymal stem cell sheets[J].Exp Ther Med,2017,14(6):5717-5726.
[3] ZHAO R, XIE PF, ZHANG K, et al. Selective effect of hydroxyapatite nanoparticles on osteoporotic and healthy bone formation correlates with intracellular calcium homeostasis regulation[J]. Acta Biomater, 2017, 59:338-350.
[4] CHOI Y H, HAN Y, JIN S W, et al. Pseudoshikonin Ⅰ enhances osteoblast differentiation by stimulating Runx2 and Osterix[J]. J Cell Biochem, 2018, 119(1):748-757.
[5] PEDDADA K V, PEDDADA K V, SHUKLA S K,et al.Role of curcumin in common musculoskeletal disorders:a review of current laboratory, translational, and clinical data[J].Orthop Surg,2015,7(3):222-231.
[6] XIN M, YANG Y, ZHANG D,et al.Attenuation of hind-limb suspension-induced bone loss by curcumin is associated with reduced oxidative stress and increased vitamine D receptor expression[J].Osteoporos Int,2015,26(11):2665-2676.
[7] APOSTU D, LUCACIU O, BERCE C,et al.Current methods of preventing aseptic loosening and improving osseointegration of titanium implants in cementless total hip arthroplasty:a review[J].J Int Med Res,2018,46(6):2104-2119.
[8] OKI Y, DOI K, MAKIHARA Y,et al.Effects of continual intermittent administration of parathyroid hormone on implant stability in the presence of osteoporosis:An in vivo study using resonance frequency analysis in a rabbit model[J].J Appl Oral Sci,2017,25(5):498-505.
[9] GHANEM A, KELLESARIAN S V, ABDULJABBAR T,et al.Role of osteogenic coatings on implant surfaces in promoting bone-to-implant contact in experimental osteoporosis:A systematic review and meta-analysis[J]. Implant Dent, 2017,26(5):770-777.
[10] LIU YM, HU J, LIU B,et al.The effect of osteoprotegerin on implant osseointegration in ovariectomized rats[J].Arch Med Sci,2017,13(2):489-495.
[11] ZHOU HB, HOU YF, ZHU ZM,et al.Effects of low-intensity pulsed ultrasound on implant osseointegration in ovariectomized rats[J].J Ultrasound Med,2016,35(4):747-754.
[12] HUANG YM, LIN Y, WU YS, et al. Molecular mechanisms of the inhibitory effects of jiangu granule-containing serum on RANKL-induced osteoclastogenesis[J]. Mol Med Rep, 2017, 16(6):8420-8426.
[13] 王买全,李运峰.同时应用雌激素和二膦酸盐对骨质疏松大鼠种植体骨结合的累加效应[J].实用口腔医学杂志,2016,32(5):640-644.
[14] JEBAHI S, SAOUDI M, FARHAT L,et al.Effect of novel curcumin-encapsulated chitosan-bioglass drug on bone and skin repair after gamma radiation:experimental study on a Wistar rat model[J].Cell Biochem Funct,2015,33(3):150-159.
[15] RIVA A, TOGNI S, GIACOMELLI L,et al.Effects of a curcumin-based supplementation in asymptomatic subjects with low bone density:A preliminary 24-week supplement study[J].Eur Rev Med Pharmacol Sci,2017,21(7):1684-1689.
[16] 李刚,刘莹,种铁,等.姜黄素对裸鼠人ACHN肾癌移植瘤的放射增敏作用[J].西安交通大学学报:医学版,2019,40(2):284-289.
[17] 陈之光,薛今琦,付勤,等.姜黄素对骨骼系统的影响[J].中华骨质疏松和骨矿盐疾病杂志,2016,9(3):323-329.
[18] CHEN Z, XUE J, SHEN T,et al.Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt signaling pathway[J].Int J Mol Med,2016,37(2):329-338.
[19] CHO D C, RYU K, KIM K T,et al.The therapeutic effects of combination therapy with curcumin and alendronate on spine fusion surgery in the ovariectomized rats[J].Korean J Spine,2017,14(2):35-40.
[20] 李义,张建中,宋英,等.姜黄素对去卵巢骨质疏松模型鼠的机制研究[J].中成药,2013,35(7):1359-1362.
[21] 马如风,王丽丽,左加成,等.姜黄素通过调节组织蛋白酶K改善高脂诱导C57BL/6J小鼠骨结构和骨质量的实验研究[J].中国药理学通报,2017,33(10):1446-1451.

Promotion effect of curcumin on implant osseointegration in osteoporosis rats

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 0

[1]	ZHANG Xin, JU Zhaojuan, ZHANG Jian, ZHAO Yan. Expression of TGF-β1 in scleral fibroblasts of rats with form deprivation myopia and regulation of Wnt/β-catenin signaling pathway [J]. Journal of Jilin University(Medicine Edition), 2019, 45(04): 861-866.
[2]	WANG Ye, WANG Hong, ZHANG Shujian, JI Huayi, JIN Zhengyong. Intervention effect of glutamine on hyperoxia lung injury in neonatal rats and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2019, 45(04): 747-751.
[3]	JIAO Guangmei, SHAN Hailei, DOU Zhijie, ZHAO Liang, ZHANG Xiaoxuan, KANG Lingling, MA Zheng, YANG Ning. Effect of nerve growth factor on expression level of growth differentiation factor-15 in brain tissue of rats with cerebral infarction [J]. Journal of Jilin University(Medicine Edition), 2019, 45(03): 572-576.
[4]	WANG Xuemin, DENG Shurong, PENG Lingling, PAN Maohua, PAN Yuzheng. Dynamic changes of pulmonary morphology and mast cell activity in rats after tracheotomy and intubation and their significances [J]. Journal of Jilin University(Medicine Edition), 2019, 45(02): 262-267.
[5]	FENG Jingyuan, LI Shucheng, WANG Hong, HUANG Xiansheng, ZHANG Aiwen, WANG Wenfeng. Improvement effect of curcumin on Renin-angiotensin-aldosterone system and heart funotion in rats with chronic heart failure [J]. Journal of Jilin University(Medicine Edition), 2019, 45(02): 325-330.
[6]	ZHANG Kesong, XU Xiaolin, HAN Qing, ZOU Yun, CHEN Bingpeng, YANG Kerong, JIANG Hao, WANG Jincheng. Application of orthopedic metal artifact reduction technology in CT examination of arthroplasty [J]. Journal of Jilin University(Medicine Edition), 2019, 45(01): 179-183.
[7]	MAO Yong, LIU Hao, WU Xiangyang, GAO Bingren. Effects of extremely low frequency electromagnetic fields exposure on function and morphology of liver,kidney and spleen of SD rats [J]. Journal of Jilin University(Medicine Edition), 2018, 44(06): 1120-1123.
[8]	ZHU Xurong, YAN Yue, DI Zhengli, WANG Tianzhong, HE Fang, WANG Xinlai, GAO Xiaoyu, ZHENG Xuejiao. Expression of miRNA-155 in cerebral cortex tissue of rats with cerebral ischemia-reperfusion injury and its significance [J]. Journal of Jilin University(Medicine Edition), 2018, 44(06): 1144-1149.
[9]	YAO Mang, HUANG Huijie, LIU Lina, FENG Lijuan. Effects of acetaminophen on hemodynamics, left ventricular function and plasma level of brain natriuretic peptide of premature young rats [J]. Journal of Jilin University(Medicine Edition), 2018, 44(06): 1230-1234.
[10]	ZHAO Yan, ZHANG Xin, ZHANG Jian, TIAN Shiqi, CHANG Yingxia. Protective effect of Qijudihuang Pill on retinal structures of glaucoma model rats and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2018, 44(05): 994-998.
[11]	LI Jun, YAO Jing, WANG Guofang, XIN Qin, CUI Likun, QI Ruxia. Clearance effect of IL-33 on amyloid β-protein in brain tissue of modelrats with Alzheimer's disease and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2018, 44(05): 908-913.
[12]	FAN Dongyan, WANG Ping, REN Hailong, ZHOU Yulai, SHI Yan. Influence of Tibetan plateau environment in development and morphology of main organs of offsprings of migrated rats [J]. Journal of Jilin University(Medicine Edition), 2018, 44(05): 914-918.
[13]	YAN Hui, LOU Shilei, MIAO Yongdi, QI Rui, GUO Zishuo, SUN Cong. Isolation,culture and identification of primary fibroblasts from rat colon [J]. Journal of Jilin University Medicine Edition, 2018, 44(04): 849-852.
[14]	DING Ziqing, WANG Weiqian, JIN Dongmei, YU Guang, XUAN dongying. Evaluation on clinical application of Florida probes in probing peri-implantsoft tissue [J]. Journal of Jilin University Medicine Edition, 2018, 44(03): 592-596.
[15]	LI Xining, CHEN Xiaochun, ZHU Yunfei, CAO Jingnan, ZOU Yiting, DU Xiao, WANG Qichun. Effect of PERK signaling pathway on osteoblast differentiation of female rats with experimental postmenopausal osteoporosis [J]. Journal of Jilin University Medicine Edition, 2018, 44(02): 260-264.