Abstract:

Abstract:Objective To observe  the efficacies of GP chemotherapy and GP chemotherapy combined with Aidi injection in treatment of advanced non-small cell lung cancer (NSCLC) in elder patients and clarify the essentiality of Aidi injection for treating elder patients with advanced NSCLC.Methods 68 patients beyond 60 years old with advanced NSCLC were randomly divided into combined treatment group and GP group.The patients in treatment group received both GP chemotherapy and Aidi injection,the patients in GP group received GP chemotherapy only.The efficacy was analyzed after at least two cycles. Results The short-term effect had no significant difference between two groups(P>0.05).The elevated rate of Karnofsky score in two groups was significantly different(P<0.05).The incidence rate of leucopenia in combined treatment group was significantly lower than that in GP group (P<0.05).The incidence rate of gastrointestinal tract and the damage of liver and renal in combined treatment group were lower than those in GP group,but there were no significant differences(P>0.05).Conclusion Aidi injection combined with GP chemotherapy has significant effect on improving quality of life and reducing the side effects of chemotherapy in elder patients with advanced NSCLC.

Key words: carcinoma,non-small cell lung;drug therapy;Aidi injection;gemcitabine;cisplatin