院内二次感染对肝硬化患者死亡风险水平的影响

doi:10.13481/j.1671-587x.20150429

Abstract

Abstract:

Objective To investigate the relationship between the second infection and the mortality of the patients with cirrhosis, and to elucidate the influence of the second infection in the risk of death of the patients with cirrhosis. Methods A total of 103 patients with cirrhosis were enrolled and divided into first infection group (n=78) and second infection group (n=25).The basic characteristics,model for end-stage liver disease (MELD) scores,serum albumin levels,microorganisms and mortality rates in 30 d as well as the incidence of infection in parts of body of the patients in two groups were compared,and the risk factors for death in the patients with cirrhosis were analyzed by multivariate Logistic regression model. Results The mortality of the patients in second infection group was significantly higher than that in first infection group (P<0.05).The incidence of pneumonia and clostridium difficile-associated diarrhea (CDAD) of the patients in second infection group was significantly increased compared with first infection group (P<0.05).Logistic regression analysis illustrated that the higher MELD scores (OR=1.293,P<0.0001),existence of second infection (OR=4.582,P=0.0002) and lower serum albumin level (OR=0.487,P=0.0387) were the independent risk factors for the death in patients with cirrhosis. Conclusion Second infection independently increase the risk of death of the hospitalized patients with cirrhosis.

Key words: infection, cirrhosis, mortality, Logistic regression model

CLC Number:

R575.2

CHEN Lin, YUAN Hong, ZHU Longdong, YUE Wei, LI Min, CHENG Zeyi, LI Wenxuan. Influence of second infection in risk of death of hospitalized patients with cirrhosis[J].Journal of Jilin University Medicine Edition, 2015, 41(04): 820-824.

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Influence of second infection in risk of death of hospitalized patients with cirrhosis

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