Abstract:

Objective: To detect the expressions of metadherin (MTDH) and matrix metalloproteinase-9 (MMP-9) in breast cancer and paired adjacent normal breast tissues of the patients with basal-like breast carcinoma (BLBC) and to analyze their correlation. Methods: The expressions of MTDH and MMP-9 in breast cancer and paired adjacent normal breast tissues of 60 BLBC patients were detected by immunohistochemistry method.Pearman analysis was used to detect the correlation between the positive expression rates of MTDH and MMP-9. Results: The positive expression rates of MTDH and MMP-9 in breast cancer tissue were higher than those in paired adjacent normal breast tissue(P<0.05).The expressions of MTDH and MMP-9 in breast cancer tissue were positively correlated with lymph node metastasis and TNM staging of the BLBC patients (P<0.05).The positive expression rates of MTDH and MMP-9 in the BLBC patients with positive lymph node metastasis were much higher than those in the BLBC patients without lymph node metastasis (χ²=6.89,P<0.05;χ²=15.22,P<0.01);the positive expression rates of MTDH and MMP-9 in the BLBC patients in Ⅲ+Ⅳ stage were much higher than those of the BLBC patients in Ⅰ+Ⅱ stage(χ²=6.431,P<0.05;χ²=8.014,P<0.05).There was a positive correlation between the expression of MTDH and the expression of MMP-9 in breast cancer tissue of the BLBC patients (r=0.531,P<0.01). Conclusion: The expression of MTDH is positive correlated with the expression of MMP-9 in breast cancer tissue of the BLBC patients;furthermore,MTDH and MMP-9 protein may play an important role in the carcinogenesis and development of BLBC.

Key words: breast neoplasms, basal-like breast carcinoma, metadherin, matrix metalloproteinase 9