PLA2G12A基因多态性与中国北方汉族儿童孤独症谱系障碍的关联性分析

doi:10.13481/j.1671-587x.20160616

Abstract

Abstract:

Objective: To investigate the association between PLA2G12A polymorphism and autism spectrum disorder (ASD) in North Han Chinesechildren,and to explore whether PLA2G12A is a susceptibility gene for ASD.Methods: A total of 85 ASD children (case group) and 183 healthy children(control group) were enrolled in our case-control study.Four SNPs (rs6533451,rs2285714,rs2285713,and rs11728699) on PLA2G12A gene were selected and the genotype and allele were tested using Sequenom Mass ARRAY System.The SNPStats program was used for analyzing the Hardy-Weinberg equilibrium test;the differences in genotypic and allelic frequencies of the subjects between two groups were detected; the association between ASD and 4 SNPs was analyzed by genetic models; the Haploview 4.2 software was used to analyze the association between ASD and haplotypes.Results: The distribution of genotypes and alleles of all SNPs sites did not deviate from Hardy-Weinberg equilibrium in both case and control groups (P>0.05). There were no significant differences of the genotypic and allelic frequencies of four SNPs sites of the subjects between case and control groups (P>0.05). There were no significant association between ASD and the gene polymorphisms of four SNPs sites under five genetic models (P>0.05).The haplotypes composed by rs251684,rs2307279,and rs156631 sites were not significantly associated with ASD (P>0.05).Conclusion: PLA2G12A may not be a candidate gene for ASD in North Han Chinese children.

Key words: PLA2G12A gene, autism spectrum disorder, case, single nucleotide polymorphism, control

CLC Number:

R729

LEI Jie, QIU Shuang, LIU Shicheng, PENG Bo, LI Ri, BAI Ye, LIU Yawen, YU Yaqin, ZHU Xiaojuan, JIANG Huiyi. Analysis on association between PLA2G12A polymorphisms and autism spectrum disorder of Han nationality children in North China[J].Journal of Jilin University Medicine Edition, 2016, 42(06): 1132-1137.

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Analysis on association between PLA2G12A polymorphisms and autism spectrum disorder of Han nationality children in North China

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