Journal of Jilin University(Medicine Edition) ›› 2022, Vol. 48 ›› Issue (2): 518-526.doi: 10.13481/j.1671-587X.20220232
• Methodology • Previous Articles Next Articles
Dongyang XING1,Suyan TIAN2,Yukun CHEN3,Jinmei WANG4,Xuejuan SUN5,Shanji LI6,Jiancheng XU1()
Received:
2021-07-06
Online:
2022-03-28
Published:
2022-05-10
Contact:
Jiancheng XU
E-mail:xjc@jlu.edu.cn
CLC Number:
Dongyang XING,Suyan TIAN,Yukun CHEN,Jinmei WANG,Xuejuan SUN,Shanji LI,Jiancheng XU. Establishment of differential diagnostic model for COVID-19 and influenza A based on laboratory indicators and its clinical significance[J].Journal of Jilin University(Medicine Edition), 2022, 48(2): 518-526.
Tab.1
Equipment informations of four designated tertiary hospitals"
Hospital | Biochemical equipment | Hematological equipment | |
---|---|---|---|
First Hospital of Jilin University | |||
Instrument | 7600-210 | XN-9000 | CS-5100 |
Manufacturer | Hitachi High-Technologies | Sysmex Corp. | Sysmex Corp. |
Origin | Tokyo, Japan | Hyogo, Japan | Hyogo, Japan |
Changchun Infectious Disease Hospital | |||
Instrument | CS-T300 | DF53 | OCG-102 |
Manufacturer | Dirui Industrial Co. | Dymind Biotechnology Co | Wondfo Biotech Co. |
Origin | Changchun, China | Shenzhen, China | Guangzhou, China |
Siping Infectious Disease Hospital | |||
Instrument | Pointcare M3i | ABX Pentra XL 80 | CS-2500 |
Manufacturer | Mnchip Technology Co. | Horiba Medical | Sysmex Corp. |
Origin | Tianjin, China | Montpellier, France | Hyogo, Japan |
Jilin Infectious Disease Hospital | |||
Instrument | AU480 | XN-1000 | SF-8100 |
Manufacturer | Beckman Coulter Inc. | Sysmex Corp. | Beijing Succeeder Technology Inc. |
Origin | Brea, the United States | Hyogo, Japan | Beijing, China |
Tab. 2
Baseline characteristics of patients with COVID-19 and influenza A"
Item | COVID-19 (n=56) | Influenza A (n=54) | P |
---|---|---|---|
Hospitalized time(t/d) | 18 (15-20) 18 (11-20) | 7 (5-10) 6 (4-9) | <0.001 |
Male | 31 (55.4) | 36 (66.7) | 0.246 |
Age(year) | 40 (28-51) | 63 (48-71) | <0.001 |
Clinical characteristics | |||
Fever | 46 (82.1) | 29 (53.7) | 0.002 |
Cough | 44 (78.6) | 19 (35.2) | <0.001 |
Hemoptysis | 1 (1.8) | 1 (1.9) | 0.743 |
Headache | 6 (10.7) | 2 (3.7) | 0.271 |
Chest pain | 2 (3.6) | 2 (3.7) | 0.677 |
Fatigue | 20 (35.7) | 9 (16.7) | 0.030 |
Muscle pain | 9 (16.1) | 4 (7.4) | 0.238 |
Dyspnea | 6 (10.7) | 11 (20.4) | 0.193 |
Abdominal pain or diarrhea | 6 (10.7) | 6 (11.1) | 0.593 |
Data were presented as median (P25-P75) or No.(%). |
Tab. 3
Basic information of COVID-19 and H1N1 patients for model validation"
Item | COVID-19 (n=24) | Influenza A (n=30) | P |
---|---|---|---|
Hospitalized time(t/d) | 21 (19-24) 18 (11-20) | 3 (2-4) 6 (4-9) | <0.001 |
Male | 11 (46) | 17 (57) | 0.429 |
Age(year) | 40 (31-49) | 54 (40-72) | 0.011 |
Clinical characteristics | |||
Fever | 20 (83) | 16 (53) | 0.020 |
Cough | 15 (63) | 8 (27) | 0.008 |
Hemoptysis | 1 (4) | 0 (0) | 0.690 |
Headache | 4 (17) | 2 (7) | 0.245 |
Chest pain | 1 (4) | 0 (0) | 0.259 |
Fatigue | 9 (38) | 4 (13) | 0.039 |
Muscle pain | 3 (13) | 2 (7) | 0.462 |
Dyspnea | 2 (8) | 1 (3) | 0.425 |
Abdominal pain or diarrhea | 1 (4) | 1 (3) | 0.872 |
Data were presented as median (P25-P75) or No. (%). |
Tab. 4
Laboratory findings at onset to hospital admission"
Parameter | Reference interval | COVID-19 [M (P25-P75)] | Influenza A [M (P25-P75)] | P |
---|---|---|---|---|
Hematological parameter | ||||
WBC(×109 L-1) | 3.50-9.50 | 5.22 (3.90-6.30) | 7.33(5.44-9.40) | <0.001 |
NE (×109 L-1) | 1.80-6.30 | 3.45 (2.48-4.38) | 5.43 (3.73-6.59) | <0.001 |
LY (×109 L-1) | 1.10-3.20 | 1.35 (0.90-1.66) | 1.20 (0.70-1.49) | 0.049 |
EO (×109 L-1) | 0.02-0.52 | 0.03 (0.00-0.04) | 0.08 (0.00-0.12) | 0.094 |
BA(×109 L-1) | 0.00-0.06 | 0.02 (0.00-0.03) | 0.03 (0.01-0.04) | 0.199 |
MO (×109 L-1) | 0.10-0.60 | 0.36 (0.24-0.50) | 0.59 (0.40-0.76) | <0.001 |
RBC (×1012 L-1) | 4.30-5.80 | 4.69 (4.29-5.09) | 4.08 (3.40-4.66) | <0.001 |
HGB(g·L-1) | 130.00-175.00 | 145.00 (133.00-158.00) | 125.98 (104.00-142.50) | <0.001 |
HCT (L·L-1) | 0.40-0.50 | 0.42 (0.39-0.45) | 0.37 (0.31-0.42) | <0.001 |
MCV (fL) | 82.00-100.00 | 89.68 (86.58-92.60) | 91.34 (87.15-93.55) | 0.201 |
MCH (pg) | 27.00-34.00 | 30.82 (30.00-32.03) | 30.90 (29.60-32.45) | 0.810 |
MCHC (g·L-1) | 316.00-354.00 | 344.69 (340.75-349.00) | 337.79 (327.50-347.50) | <0.001 |
RDW (%) | 11.00-16.00 | 11.65 (11.20-11.90) | 13.76 (12.55-14.65) | <0.001 |
Platelets (×109 L-1) | 125.00-350.00 | 201.83 (159.25-230.50) | 193.08 (125.00-281.00) | 0.342 |
MPV (fL) | 6.50-12.00 | 9.40 (8.58-10.10) | 10.79 (9.70-11.55) | <0.001 |
PDW (%) | 9.00-17.00 | 12.81 (10.65-14.35) | 12.32 (10.50-12.90) | 0.216 |
PCT (%) | 0.11-0.29 | 0.19 (0.14-0.20) | 0.20 (0.14-0.29) | 0.485 |
Biochemical parameter | ||||
AST (U·L-1) | 13.00-40.00 | 29.30 (20.00-30.00) | 52.50 (18.20-78.35) | 0.041 |
ALT (U·L-1) | 7.00-50.00 | 34.23 (19.00-45.00) | 43.25 (12.80-63.95) | 0.617 |
GGT (U·L-1) | 7.00-60.00 | 34.30 (15.00-40.00) | 72.33 (18.50-113.70) | <0.001 |
CHE (U·L-1) | 5 000-12 000 | 8 032 (6 885-9 045) | 4 865 (3 811-5 828) | <0.001 |
TP (g·L-1) | 65.0-85.0 | 68.43 (65.00-72.00) | 60.60 (56.30-64.60) | <0.001 |
ALB (g·L-1) | 40.0-55.0 | 44.30 (42.20-45.90) | 30.95 (26.55-35.70) | <0.001 |
GLB (g·L-1) | 20.0-40.0 | 24.08 (21.60-26.70) | 29.65 (26.35-33.30) | <0.001 |
A/G | 1.20-2.40 | 1.89 (1.66-2.06) | 1.08 (0.86-1.18) | <0.001 |
TBIL (μmol·L-1) | ≤23.00 | 10.00 (6.70-13.20) | 19.61 (9.80-25.50) | <0.001 |
DBIL(μmol·L-1) | ≤8.00 | 4.10 (3.10-5.10) | 8.78 (3.00-9.55) | <0.001 |
IBIL (μmol·L-1) | 5.10-21.40 | 5.87 (3.40-7.50) | 10.83 (6.45-13.15) | <0.001 |
Urea (mmol·L-1) | 3.10-8.00 | 3.96 (3.07-4.75) | 6.12 (3.88-8.24) | <0.001 |
Cr (μmol·L-1) | 57.00-97.00 | 67.90 (57.50-77.00) | 70.08 (47.25-84.38) | 0.207 |
CO2-CP (mmol·L-1) | 22.00-29.00 | 20.74 (18.9-22.4) | 25.78 (24.23-27.80) | <0.001 |
Glu (mol·L-1) | 3.89-6.11 | 6.62 (5.53-6.79) | 6.38 (5.01-7.26) | 0.392 |
K+ (mmol·L-1) | 3.50-5.30 | 4.14 (3.90-4.40) | 3.95 (3.60-4.30) | 0.036 |
Na+ (mmol·L-1) | 137.00-147.00 | 138.50 (137.00-140.00) | 136.74 (134.00-140.00) | 0.021 |
Cl- (mmol·L-1) | 99.00-110.00 | 99.73 (97.25-102.00) | 101.54 (98.00-104.00) | 0.030 |
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