组蛋白乙酰化修饰对牙周炎发生发展影响的研究进展

doi:10.13481/j.1671-587X.20240533

Abstract

Abstract:

Periodontitis is a chronic inflammatory disease caused by plaque biofilm， and the homeostasis of the periodontal microenvironment is crucial for periodontal health. The epigenetics explores how the environmental and other non-genetic factors regulate the gene expression without changing the DNA nucleotide sequence， thereby affecting the occurrence and development of this disease. The histone acetylation modification is one of the common epigenetic modifications， primarily regulated by the histone acetyltransferases and histone deacetylases. Imbalance in this regulation can lead to the gene regulatory disorders， causing the chronic inflammation， autoimmune diseases and cancer. Recent studies have shown there is a clear correlation between histone acetylation modifications and the development of periodontitis. This paper discusses the changes in histone acetylation modifications in the gingival epithelial cells， immune cells， and periodontal ligament stem cells during periodontitis， elucidating the role and molecular mechanisms of histone acetylation modifications in the development of periodontitis and providing the basis for the epigenetic treatment of periodontitis.

Key words: Epigenetics, Histone acetylation modification, Gene transcription, Periodontitis, Epigenetic therapy

CLC Number:

R781.4

Yi XIE,Yang LIU,Hongyan LI,Xiaowei XU. Research progress in effect of histone acetylation modifications on occurrence and development of periodontitis[J].Journal of Jilin University(Medicine Edition), 2024, 50(5): 1457-1464.

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Research progress in effect of histone acetylation modifications on occurrence and development of periodontitis

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