Hedgehog信号通路磷酸化修饰在肿瘤发生发展中作用的研究进展

doi:10.13481/j.1671-587X.20250228

Abstract

Abstract:

The Hedgehog （HH） signaling pathway is involved in various developmental processes of vertebrates and invertebrates，including embryogenesis，stem cell renewal，tissue regeneration，the occurrence and development of tumor and chemotherapy resistance. Overactivation and abnormal expression of key components in the HH signaling pathway are associated with the development of various malignant tumors. Phosphorylation plays an important role in regulating the activity and function of proteins in normal cells， and the disorder of phosphorylation-dephosphorylation cascade is closely related to tumorigenesis. The abnormal activation of this signaling pathway is also related to protein phosphorylation，while its complex underlying mechanism needs to be further explored. This article reviewed the research progress of the HH signaling pathway and protein phosphorylation modification in malignant tumors， focusing on the regulatory effect of phosphorylation modification on the activity of HH signaling pathway and its effect on the occurrence and development of malignant tumors，in order to provide a theoretical basis for the in-depth development and clinical application of targeted drugs for phosphatase/dephosphatase.

Key words: Tumor, Hedgehog signaling pathway, Protein phosphatase, Dephosphorylation

CLC Number:

R730.2

Xin ZHANG,Fei WANG,Bingjie CUI,Jing DU. Research progress in effect of phosphorylation modification of Hedgehog signaling pathway on occurrence and development of tumor[J].Journal of Jilin University(Medicine Edition), 2025, 51(2): 526-533.

Figures/Tables 2

References 64

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Research progress in effect of phosphorylation modification of Hedgehog signaling pathway on occurrence and development of tumor

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