cT1-2N0期乳腺癌腋窝淋巴结转移相关因素分析

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Analysis on related factors of axillary lymph node metastasis in patients with cT_1-2N₀ breast cancer

Analysis on related factors of axillary lymph node metastasis in patients with cT1-2N0 breast cancer

Analysis on related factors of axillary lymph node metastasis in patients with cT_1-2N₀ breast cancer

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Abstract

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doi:10.13481/j.1671-587x.20150627

Abstract:

Objective To investigate the relationships between axillary lymph node metastasis and clinicopathologic features in the patients with cT_1-2N₀ breast cancer and clarify the law of axillary lymph node metastasis,and to find the risk factor,and provide the theoretical basis for individuation therapy. Methods 687 patients with cT_1-2N₀ breast cancer were divided into negative group and positive group according to the pathological results of axillary lymph node, and the clinicopathologic features were layered.The risk factors of axillary lymph node metastasis were screened out by Chi-square test and Logistic regression analysis. Results In 687 cases of cT_1-2N₀ breast cancer,156 (22.7%) cases were observed with axillary lymph node metastasis. The age,cT stage,pT stage,pathological type,vascular invasion,perineural invasion estrogen receptor(ER), progesterone receptor(PR),and molecular subtyping were the factors that influenced axillary lymph node metastasis in univariate analyses.The age<35 years,cT₂,invasive ductal carcinoma,vascular invasion positive and Luminal subtyping were the independent risk factors of axillary lymph nodes metastasis in multivariate analyses(r=3.440,P=0.010;r=1.770,P=0.007;r=3.397,P=0.001;r=7.434,P=0.000;r=2.212,P=0.015). Conclusion In the patients with cT_1-2N₀ breast cancer,the age, cT,pathological type, vascular invasion and molecular subtyping are important predictors of axillary lymph node metastasis and vascular invasion was the most important predictor.The preoperative comprehensive analysis and evaluation of clinical data and preoperative pathological results obtained will help to select the right surgical operation.

Key words: breast neoplasms, neoplasms staging, axillary lymph node metastasis, ultrasonic diagnosis, vascular invasion, Luminal subtyping

CLC Number:

R737.9

CUI Zhushan, DU Ye, ZHU Zhu, GAO Pin, LI Jiawei, FAN Zhimin. Analysis on related factors of axillary lymph node metastasis in patients with cT_1-2N₀ breast cancer[J].Journal of Jilin University Medicine Edition, 2015, 41(06): 1239-1244.

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