Journal of Jilin University(Medicine Edition) ›› 2022, Vol. 48 ›› Issue (6): 1382-1388.doi: 10.13481/j.1671-587X.20220602
• Research in basic medicine • Previous Articles Next Articles
Lingling FAN1,2,Shuping DING3,Guomin SHEN1,2,Zhihong HU1,Aihong REN1,Bo DENG1
Received:
2022-01-30
Online:
2022-11-28
Published:
2022-12-07
Contact:
Guomin SHEN
CLC Number:
Lingling FAN,Shuping DING,Guomin SHEN,Zhihong HU,Aihong REN,Bo DENG. Effect of mediodorsal thalamic nucleus lesions on electrical activity in medial prefrontal cortex of rats with Parkinson’s disease[J].Journal of Jilin University(Medicine Edition), 2022, 48(6): 1382-1388.
Tab. 1
Firing frequencies and coefficients of variation of ISI of pyramidal neurons in mPFC of rats in various groups"
Group | Number of neurons | Firing frequency (Hz) | Coefficient of variation of ISI |
---|---|---|---|
Normal | 59 | 1.26±0.12 | 1.20±0.07 |
SNc lesion | 47 | 2.12±0.25* | 1.59±0.07** |
MD lesion | 56 | 2.36±0.27** | 1.74±0.11** |
SNc+MD lesion | 57 | 1.58±0.18 | 1.59±0.06** |
1 | NIELSEN N S, SKOVBOLLING S L. Non-motor symptoms in Parkinson’s disease[J]. Ugeskr Laeger, 2021, 183(27): V01210089. |
2 | MARTINEZ B, PEPLOW P V. Neuroprotection by immunomodulatory agents in animal models of Parkinson’s disease[J].Neural Regen Res,2018,13(9): 1493-1506. |
3 | SQUIRE L R, MOORE R Y. Dorsal thalamic lesion in a noted case of human memory dysfunction[J]. Ann Neurol, 1979, 6(6): 503-506. |
4 | VICTOR M, ADAMS R D, COLLINS G H. The Wernicke-Korsakoff syndrome. A clinical and pathological study of 245 patients, 82 with post-mortem examinations[J]. Contemp Neurol Ser, 1971, 7: 1-206. |
5 | YOUNG K A, HOLCOMB L A, YAZDANI U, et al. Elevated neuron number in the limbic thalamus in major depression[J]. Am J Psychiatry, 2004, 161(7): 1270-1277. |
6 | LI W, LIU J, SKIDMORE F, et al. White matter microstructure changes in the thalamus in Parkinson disease with depression: a diffusion tensor MR imaging study[J]. AJNR Am J Neuroradiol, 2010, 31(10): 1861-1866. |
7 | CARDOSO E F, MAIA F M, FREGNI F, et al. Depression in Parkinson’s disease: convergence from voxel-based morphometry and functional magnetic resonance imaging in the limbic thalamus[J]. NeuroImage, 2009, 47(2): 467-472. |
8 | LI W J, XI Y, ZHANG Q J, et al. Neuronal firing activity changes in mediodorsal thalamus nucleus in rats with Parkinson’s disease [J]. J Xi’an Jiaotong Univ Med Sci, 2013,34(5): 614-618 |
9 | 范玲玲, 邓 博, 闫君宝, 等. 5-羟色胺-7受体激动剂对帕金森病模型大鼠内侧前额叶皮层锥体神经元兴奋性的影响[J]. 南方医科大学学报, 2016, 36(6): 756-762. |
10 | RIDDERINKHOF K R, ULLSPERGER M, CRONE E A, et al. The role of the medial frontal cortex in cognitive control[J].Science,2004,306(5695): 443-447. |
11 | GIL SALADIÉ D, DELGADO GONZÁLEZ M, OLIVERAS LEY C, et al. Depression in Parkinson’s disease and its relation to the cognitive and motor manifestations[J]. Neurologia, 1992, 7(7): 176-180. |
12 | CROSS L, BROWN M W, AGGLETON J P, et al. The medial dorsal thalamic nucleus and the medial prefrontal cortex of the rat function together to support associative recognition and recency but not item recognition[J]. Learn Mem, 2012, 20(1): 41-50. |
13 | CONSTANTINIDIS C, GOLDMAN-RAKIC P S. Correlated discharges among putative pyramidal neurons and interneurons in the primate prefrontal cortex[J]. J Neurophysiol, 2002, 88(6): 3487-3497. |
14 | WALSH J J, HAN M H. The heterogeneity of ventral tegmental area neurons: projection functions in a mood-related context[J]. Neuroscience, 2014, 282: 101-108. |
15 | LEWIS B L, O’DONNELL P. Ventral tegmental area afferents to the prefrontal cortex maintain membrane potential ‘up’ states in pyramidal neurons via D(1) dopamine receptors[J]. Cereb Cortex, 2000, 10(12): 1168-1175. |
16 | WANG J, O’DONNELL P. D(1) dopamine receptors potentiate nmda-mediated excitability increase in layer Ⅴ prefrontal cortical pyramidal neurons[J]. Cereb Cortex, 2001, 11(5): 452-462. |
17 | TSENG K Y, O'DONNELL P. Dopamine-glutamate interactions controlling prefrontal cortical pyramidal cell excitability involve multiple signaling mechanisms[J]. J Neurosci, 2004, 24(22): 5131-5139. |
18 | WANG Q, WANG P H, MCLACHLAN C, et al. Simvastatin reverses the downregulation of dopamine D1 and D2 receptor expression in the prefrontal cortex of 6-hydroxydopamine-induced Parkinsonian rats[J]. Brain Res, 2005, 1045(1/2): 229-233. |
19 | FILION M. Effects of interruption of the nigrostriatal pathway and of dopaminergic agents on the spontaneous activity of globus pallidus neurons in the awake monkey[J]. Brain Res, 1979, 178(2/3): 425-441. |
20 | CRUIKSHANK S J, URABE H, NURMIKKO A V, et al. Pathway-specific feedforward circuits between thalamus and neocortex revealed by selective optical stimulation of axons[J]. Neuron, 2010,65(2): 230-245. |
21 | FERRON A, THIERRY A M, LE DOUARIN C,et al. Inhibitory influence of the mesocortical dopaminergic system on spontaneous activity or excitatory response induced from the thalamic mediodorsal nucleus in the rat medial prefrontal cortex[J]. Brain Res, 1984, 302(2): 257-265. |
22 | GIGG J, TAN A M, FINCH D M. Glutamatergic excitatory responses of anterior cingulate neurons to stimulation of the mediodorsal thalamus and their regulation by GABA: an in vivo iontophoretic study[J]. Cereb Cortex, 1992, 2(6): 477-484. |
23 | KURODA M, YOKOFUJITA J, MURAKAMI K. An ultrastructural study of the neural circuit between the prefrontal cortex and the mediodorsal nucleus of the thalamus[J]. Prog Neurobiol, 1998, 54(4): 417-458. |
24 | DELEVICH K, TUCCIARONE J, HUANG Z J,et al. The mediodorsal thalamus drives feedforward inhibition in the anterior cingulate cortex via parvalbumin interneurons[J]. J Neurosci, 2015, 35(14): 5743-5753. |
25 | TIMBIE C, BARBAS H. Pathways for emotions: specializations in the amygdalar, mediodorsal thalamic, and posterior orbitofrontal network[J]. J Neurosci, 2015, 35(34): 11976-11987. |
26 | MANTZ J, GODBOUT R, TASSIN J P, et al. Inhibition of spontaneous and evoked unit activity in the rat medial prefrontal cortex by mesencephalic raphe nuclei[J]. Brain Res, 1990, 524(1): 22-30. |
27 | HASSLER R, HAUG P, NITSCH C, et al. Effect of motor and premotor cortex ablation on concentrations of amino acids, monoamines, and acetylcholine and on the ultrastructure in rat striatum. A confirmation of glutamate as the specific cortico-striatal transmitter[J]. J Neurochem, 1982, 38(4): 1087-1098. |
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