小檗碱抗肿瘤机制及其新型纳米递送系统在肿瘤治疗中应用的研究进展

doi:10.13481/j.1671-587X.20260329

Abstract

Abstract:

Berberine is a kind of small-molecule isoquinoline alkaloid extracted from Chinese herbal medicines such as Coptis chinensis， and its anti-tumor effect has attracted extensive attention. It exerts anti-tumor effects through multiple mechanisms， including arresting cell cycle， inducing tumor cell apoptosis， promoting autophagy， inhibiting tumor metastasis， and activating the anti-tumor immune response of the body. Berberine has the problems of low bioavailability and poor stability in vivo， which limit its clinical application. A variety of nanomaterials such as polymeric nanoparticles， metal-organic frameworks and liposomes have been innovatively applied to the delivery of berberine. This paper discussed the therapeutic effects and action mechanisms of berberine in various tumors， and analyzed the application status of berberine nano-drug delivery system in the field of cancer treatment， so as to provide theoretical basis and practical guidance for the further optimization and innovation of cancer treatment strategies， and promote the transformation of relevant research achievements into clinical application.

Key words: Berberine, Anti-tumor therapy, Apoptosis, Immune regulation, Nanomaterial

CLC Number:

R285

Qiuping SU,Lei XING,Wei ZHANG,Shan JIANG,Yangyang ZHAO,Fangfang CHEN. Research progress in anti-tumor mechanism of berberine and application of its novel nano-delivery system in tumor therapy[J].Journal of Jilin University(Medicine Edition), 2026, 52(3): 863-871.

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Research progress in anti-tumor mechanism of berberine and application of its novel nano-delivery system in tumor therapy

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