吉林大学学报(工学版) ›› 2015, Vol. 45 ›› Issue (4): 1367-1374.doi: 10.13229/j.cnki.jdxbgxb201504049

• • 上一篇    下一篇

仿骨β相磷酸三钙多孔生物陶瓷制备及降解

马云海, 尚文博, 范雪莹, 高知辉, 佟金, 闫志峰, 常志勇   

  1. 吉林大学 生物与农业工程学院,长春 130022
  • 收稿日期:2014-08-22 出版日期:2015-07-01 发布日期:2015-07-01
  • 通讯作者: 常志勇(1980-)男,工程师.研究方向:仿生材料及生物材料.E-mail:zychang@jlu.edu.cn
  • 作者简介:马云海(1970-)男,教授.研究方向:仿生材料及生物材料.E-mail:myh@jlu.edu.cn
  • 基金资助:
    吉林省科技发展计划项目(20130101043JC,20150519022JH, 20120716); 国家自然科学基金项目(51475205); 长春市科技发展计划项目(14KG033); 土壤植物机器系统技术国家重点实验室开放课题(2014-SKL-10)

Preparation and degradation of porous β-tricalcium phosphate bioceramic for bone imitaion

MA Yun-hai, SHANG Wen-bo, FAN Xue-ying, GAO Zhi-hui, TONG Jin, YAN Zhi-feng, CHANG Zhi-yong   

  1. College of Biological and Agricultural Engineering, Jilin University, Changchun 130022, China
  • Received:2014-08-22 Online:2015-07-01 Published:2015-07-01

RICH HTML

0   

PDF (PC)

182

摘要： 以硝酸钙和2-膦酸丁烷-1,2,4-三羧酸(PBTC)为原料通过化学合成前驱体,然后脱水缩合再高温烧结的方法制备β相磷酸三钙(β-TCP)粉体,以该粉体为基体、硬脂酸为致孔剂、PVA为粘结剂,通过模压成型的方法制取胚体烧结制备β-TCP多孔生物陶瓷。通过X射线衍射分析、扫描电镜观察、EDX能谱成分分析对制备的β-TCP多孔陶瓷进行研究。对添加致孔剂质量分数分别为15%、20%、25%、30%的4组陶瓷试样进行降解试验,发现质量分数为30%的试样降解效果最好,通过扫描电镜观察和EDX分析确认表面有类羟基磷灰石物质产生。

关键词: 无机非金属材料, β, -磷酸三钙, 烧结, 多孔, 降解, X射线衍射

Abstract: In this study, porous β-tricalcium Phosphate (β-TCP) bioceramic is prepared by the following steps. First, calcium nitrate and 2-phosphonic acid-1,2,4-tricarboxylic acid (PBTC) are used as raw materials to synthesize the precursor; second, β-TCP power was prepared by dehydration concentration and high temperature sintering; third, β-TCP power is taken as the matrix, stearic acid as porogen and PVA as binder to prepare the moudles by press molding; finally, β-TCP bioceramic is prepared by sintering of the moudles. The compositions of the β-TCP bioceramic are analyzed using X-ray diffraction analysis, scanning electron microscopy and EDX spectroscopy. Degradation experiments are carried out using the specimens with four levels of porogen, 15%, 20%, 25% and 30% respectively. Results show that the specimen with 30% of porogen has the best degradation performance. EDX analysis and scanning electron microscopy observation confirm the generation of hydroxyapatite materials on the surface of the β-TCP bioceramic.

Key words: inorganic non-metallic materials, β-tricalcium phosphate, sintering, porous, degradation, X-ray diffraction

中图分类号: 

  • R683
[1] Bohner M, Van Lenthe G H, Grunenfelder S.Synthesis and characterization of porous β-tricalcium phosphate blocks[J]. Bio-materials,2005,26:6099-6105.
[2] 樊东辉,徐政,李世普,等.多孔β-TCP材料的生物降解性能及相关机理研究[J].中国康复医学杂志, 2003, 18(3):166-167. Fan Dong-hui, Xu Zheng, Li Shi-pu, et al. A study on biodegradable characteristic and mechanism of β-TCP[J]. Chinese Journal of Rehabilitation Medicine, 2003, 18(3):166-167.
[3] 徐鹏,翁云飞,王欣宇. 改进沉淀法合成β-磷酸三钙[J]. 中国医药科学,2011, 1(10):13-14. Xu Peng, Weng Yun-fei, Wang Xin-yu. Synthesis of β-tricalcium phosphate by modified percipitation reaction[J]. China Medicine and Pharmacy,2011,1(10):13-14.
[4] 何毅,刘孝波,杨德娟,等. 纳米级β-磷酸钙的合成[J]. 合成化学,2000, 8(2):96-99. He Yi, Liu Xiao-bo, Yang De-juan, et al. The synthesis of namosized β-tricalcium phosphate[J]. Chinese Journal of Synthetic Chemistry,2000, 8(2):96-99.
[5] 巩梦安, 饶群力, 王鸿烈. 造孔剂与发泡法结合制备氟化羟基磷灰石多孔支架研究[J]. 无机材料学报, 2014, 29(3): 289-293. Gong Meng-an, Rao Qun-li, Wang Hong-lie. A novel technique to prepare porous 3D fluoridared hydroxyapatite scaffold using pore-forming and hoaming agents[J]. Journal of Inorganic Materials,2014, 29(3): 289-293.
[6] Legeros R Z, Lin S, Rohanizadeh R, et al. Biphasic calcium phosphate bioceramics: preparation properties and applications[J].J Mater Sci Med, 2003,14(3):201-209.
[7] 张士华, 熊党生. β-磷酸三钙多孔生物陶瓷的制备与表征[J]. 南京理工大学学报, 2005,29(2): 231-235. Zhang Shi-hua, Xiong Dang-sheng. Preparation and characterization of β-Tricalcium phosphate porous bioceramic[J]. Journal of Nanjing University of Science and Technology, 2005, 29(2): 231-235.
[8] Moran J M, Pazzano D, Bonassar L J.Characterization of polylactic acid-polyglycolic acid composites for cartilage tissue engineering[J].Tissue Eng, 2003, 9:63-70.
[9] Cho S B, Nakanishi K, Kokubo T, et al.Dependence of apatite formation on silica gel on its structure: effect of heat treatment[J]. Journal of the American Ceramic Society, 1995, 78(7): 1769-1774.
[10] 林开利, 常江, 卢建熙,等. β-磷酸三钙/硅酸钙复合生物陶瓷的制备及性能研究[J]. 无机材料学报, 2006, 21(6): 1429-1434. Lin Kai-li, Chang Jiang, Lu Jian-xi, et al.Fabrication and characterization of β-Ca 3 (P04)2/CaSi03 composite bioceramics[J].Journal of Inorganic Materials,2006,21(6): 1429-1434.
[11] 苏葆辉, 冉旭, 冉均国,等. HA/β-TCP 双相磷酸钙陶瓷材料的生物学性能研究[J]. 稀有金属材料与工程, 2007, 36(A02): 37-39. Su Bao-hui, Ran Xu, Ran Jun-guo, et al. Study on biological properties of HA/β-TCP biphase calcium phosphate ceramic materials[J]. Rare Metal Materials and Engineering, 2007, 36(A02): 37-39.
[12] Schneider O D,Loher S,Brunner T J, et al. Cotton wool-like nanocomposite biomaterials prepared by electrospinning: In vitro bioactivity and osteogenic differentiation of human mesenchymal stem cells[J].J Biomed Mater Res, 2008b,84(2):350-362.
[1] 杨悦, 李雪, 徐晓丹. Ti-B-C-N粉末烧结的微观组织及其性能[J]. 吉林大学学报(工学版), 2017, 47(2): 552-556.
[2] 葛长江, 叶辉, 胡兴军, 于征磊. 鸮翼后缘噪声的预测及控制[J]. 吉林大学学报(工学版), 2016, 46(6): 1981-1986.
[3] 刘玉艳, 储顺礼, 李男男, 包幸福, 高尚, 沙莉, 胡敏, 蒋引珊. 不同质量比N,O-CMC/n-β-TCP复合材料在模拟体液中的降解性能[J]. 吉林大学学报(工学版), 2013, 43(增刊1): 552-556.
[4] 王永华, 张成春, 王晶, 石磊, 张雪鹏, 任露泉. 仿生多孔材料吸声性能[J]. , 2012, (06): 1442-1447.
[5] 王彬星, 郑四发, 刘海涛, 连小珉. 基于现场测量的多孔材料声学特性参数估计 [J]. , 2012, (03): 545-550.
[6] 卢广林,邱小明, 白杨,伦辛杰,邓宝清,任露泉. c-BN仿生耐磨复合材料的微观结构和耐磨性能[J]. 吉林大学学报(工学版), 2011, 41(01): 73-0077.
[7] 蒋玮,沙爱民,肖晶晶. 基于离散单元方法的多孔沥青混合料级配比选[J]. 吉林大学学报(工学版), 2011, 41(01): 68-0072.
[8] 宋博, 杨军, 张希艳, 柏朝晖, 卢利平. 燃烧法制备NaYF4:Er3+,Yb3+纳米发光粉[J]. 吉林大学学报(工学版), 2010, 40(02): 447-0451.
[9] 裴建中,王富玉,张嘉林. 基于X-CT技术的多孔排水沥青混合料空隙竖向分布特性[J]. 吉林大学学报(工学版), 2009, 39(增刊2): 215-0219.
[10] 张培萍，王丽丹，张立功，罗劲松，范翊 . Nd/Si共掺钇铝石榴石粉体的制备及其性能表征[J]. 吉林大学学报(工学版), 2009, 39(02): 354-0357.
[11] 赵仁保，岳湘安，吴亚红 . 氮气在水饱和岩心中的渗流规律[J]. 吉林大学学报(工学版), 2009, 39(01): 244-248.
[12] 赵仁保， 岳湘安， 吴亚生 . 污泥与盐酸在多孔介质中的反应及分布规律
[J]. 吉林大学学报(工学版), 2008, 38(05): 1252-1256.
[13] 张凤君，刘佳泓，马玖彤，回进 . 淀粉基可生物降解载体在同步
硝化反硝化中的应用[J]. 吉林大学学报(工学版), 2008, 38(02): 319-0322.
[14] 董宏宇，杨光敏，陈晓光，吴文福，徐强，石晓光，叶文 . 适用于谷物干燥的红外辐射陶瓷材料[J]. 吉林大学学报(工学版), 2007, 37(04): 804-808.
[15] 张培萍，刘淑凤，张立功，罗劲松，安立楠 . 高能振动球磨作用对纳米Al2O3相变温度的影响[J]. 吉林大学学报(工学版), 2006, 36(05): 715-0718.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
版权所有 © 《吉林大学学报(工学版)》编辑部
地址：长春市人民大街5988号　电话：+86-431-85095297　传真：+86-431-85094074　E-mail: xbgxb@jlu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发