吉林大学学报(工学版) ›› 2015, Vol. 45 ›› Issue (4): 1367-1374.doi: 10.13229/j.cnki.jdxbgxb201504049

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仿骨β相磷酸三钙多孔生物陶瓷制备及降解

马云海, 尚文博, 范雪莹, 高知辉, 佟金, 闫志峰, 常志勇   

  1. 吉林大学 生物与农业工程学院,长春 130022
  • 收稿日期:2014-08-22 出版日期:2015-07-01 发布日期:2015-07-01
  • 通讯作者: 常志勇(1980-)男,工程师.研究方向:仿生材料及生物材料.E-mail:zychang@jlu.edu.cn
  • 作者简介:马云海(1970-)男,教授.研究方向:仿生材料及生物材料.E-mail:myh@jlu.edu.cn
  • 基金资助:
    吉林省科技发展计划项目(20130101043JC,20150519022JH, 20120716); 国家自然科学基金项目(51475205); 长春市科技发展计划项目(14KG033); 土壤植物机器系统技术国家重点实验室开放课题(2014-SKL-10)

Preparation and degradation of porous β-tricalcium phosphate bioceramic for bone imitaion

MA Yun-hai, SHANG Wen-bo, FAN Xue-ying, GAO Zhi-hui, TONG Jin, YAN Zhi-feng, CHANG Zhi-yong   

  1. College of Biological and Agricultural Engineering, Jilin University, Changchun 130022, China
  • Received:2014-08-22 Online:2015-07-01 Published:2015-07-01

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摘要： 以硝酸钙和2-膦酸丁烷-1,2,4-三羧酸(PBTC)为原料通过化学合成前驱体,然后脱水缩合再高温烧结的方法制备β相磷酸三钙(β-TCP)粉体,以该粉体为基体、硬脂酸为致孔剂、PVA为粘结剂,通过模压成型的方法制取胚体烧结制备β-TCP多孔生物陶瓷。通过X射线衍射分析、扫描电镜观察、EDX能谱成分分析对制备的β-TCP多孔陶瓷进行研究。对添加致孔剂质量分数分别为15%、20%、25%、30%的4组陶瓷试样进行降解试验,发现质量分数为30%的试样降解效果最好,通过扫描电镜观察和EDX分析确认表面有类羟基磷灰石物质产生。

关键词: 无机非金属材料, β, -磷酸三钙, 烧结, 多孔, 降解, X射线衍射

Abstract: In this study, porous β-tricalcium Phosphate (β-TCP) bioceramic is prepared by the following steps. First, calcium nitrate and 2-phosphonic acid-1,2,4-tricarboxylic acid (PBTC) are used as raw materials to synthesize the precursor; second, β-TCP power was prepared by dehydration concentration and high temperature sintering; third, β-TCP power is taken as the matrix, stearic acid as porogen and PVA as binder to prepare the moudles by press molding; finally, β-TCP bioceramic is prepared by sintering of the moudles. The compositions of the β-TCP bioceramic are analyzed using X-ray diffraction analysis, scanning electron microscopy and EDX spectroscopy. Degradation experiments are carried out using the specimens with four levels of porogen, 15%, 20%, 25% and 30% respectively. Results show that the specimen with 30% of porogen has the best degradation performance. EDX analysis and scanning electron microscopy observation confirm the generation of hydroxyapatite materials on the surface of the β-TCP bioceramic.

Key words: inorganic non-metallic materials, β-tricalcium phosphate, sintering, porous, degradation, X-ray diffraction

中图分类号: 

  • R683
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